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Molecular mechanisms that control mouse and human TCR-αβ and TCR-γδ T cell development

Taghon, Tom and Rothenberg, Ellen V. (2008) Molecular mechanisms that control mouse and human TCR-αβ and TCR-γδ T cell development. Seminars In Immunopathology, 30 (4). pp. 383-398. ISSN 1863-2297. doi:10.1007/s00281-008-0134-3.

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Following specification of hematopoietic precursor cells into the T cell lineage, several developmental options remain available to the immature thymocytes. The paradigm is that the outcome of the T cell receptor rearrangements and the corresponding T cell receptor signaling events will be predominant to determine the first of these choices: the αβ versus γδ T cell pathways. Here, we review the thymus-derived environmental signals, the transcriptional mediators, and other molecular mechanisms that are also involved in this decision in both the mouse and human. We discuss the differences in cellular events between the αβ and γδ developmental pathways and try to correlate these with a corresponding complexity of the molecular mechanisms that support them.

Item Type:Article
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URLURL TypeDescription ReadCube access
Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© Springer-Verlag 2008. Received: 14 August 2008 / Accepted: 30 September 2008 / Published online: 17 October 2008. The authors wish to thank the many authors whose work provided important insights into the topic discussed within this manuscript but who could not be cited due to space limitations. TT is a postdoctoral fellow of the Fund for Scientific Research Flanders (FWO) and his work on this topic is supported by a grant from the FWO as well as from its Odysseus Research Program. Related work in the laboratory of EVR was supported by NIH grants CA90233 and CA98925.
Funding AgencyGrant Number
Fonds Wetenschappelijk Onderzoek - Vlaanderen (FWO)UNSPECIFIED
Subject Keywords:mouse; human; T-cell development; gene regulation; TCR-alphabeta; TCR-gammadelta; lineage commitment
Issue or Number:4
Record Number:CaltechAUTHORS:20090804-083343225
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Official Citation:Taghon, T. & Rothenberg, E.V. Semin Immunopathol (2008) 30: 383. doi:10.1007/s00281-008-0134-3
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:14778
Deposited By: Tony Diaz
Deposited On:07 Aug 2009 15:45
Last Modified:08 Nov 2021 23:14

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