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A portrait of the "SCP/TAPS" proteins of eukaryotes -- developing a framework for fundamental research and biotechnological outcomes

Cantacessi, C. and Campbell, B. E. and Visser, A. and Geldhof, P. and Nolan, M. J. and Nisbet, A. J. and Matthews, J. B. and Loukas, A. and Hofmann, A. and Otranto, D. and Sternberg, P. W. and Gasser, R. B. (2009) A portrait of the "SCP/TAPS" proteins of eukaryotes -- developing a framework for fundamental research and biotechnological outcomes. Biotechnology Advances, 27 (4). pp. 376-388. ISSN 0734-9750. https://resolver.caltech.edu/CaltechAUTHORS:20090804-100455850

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Abstract

A wide range of proteins belonging to the SCP/TAPS “family” has been described for various eukaryotic organisms, including plants and animals (vertebrates and invertebrates, such as helminths). Although SCP/TAPS proteins have been proposed to play key roles in a number of fundamental biological processes, such as host–pathogen interactions and defence mechanisms, there is a paucity of information on their genetic relationships, structures and functions, and there is no standardised nomenclature for these proteins. A detailed analysis of the relationships of members of the SCP/TAPS family of proteins, based on key protein signatures, could provide a foundation for investigating these areas. In this article, we review the current state of knowledge of key SCP/TAPS proteins of eukaryotes, with an emphasis on those from parasitic helminths, and undertake a comprehensive, systematic phylogenetic analysis of currently available full-length protein sequence data (considering characteristic protein signatures or motifs) to infer relationships and provide a framework (based on statistical support) for the naming of these proteins. This framework is intended to guide genomic and molecular biological explorations of key SCP/TAPS molecules associated with infectious diseases of plants and animals. In particular, fundamental investigations of these molecules in parasites and the integration of structural and functional data could lead to new and innovative approaches for the control of parasitic diseases, with important biotechnological outcomes.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.biotechadv.2009.02.005DOIUNSPECIFIED
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T4X-4VNKGTH-1&_user=1010281&_coverDate=08%2F31%2F2009&_rdoc=8&_fmt=high&_orig=browse&_srch=doc-info(%23toc%234986%232009%23999729995%231114071%23FLA%23display%23Volume)&_cdi=4986&_sort=d&_docanchoPublisherUNSPECIFIED
Additional Information:© 2009 Elsevier B.V. Received 10 December 2008; revised 5 February 2009; accepted 11 February 2009. Available online 21 February 2009. The research was supported by the Australian Research Council (ARC) (DP0665230; RBG and AL), the Australian Academy of Science and the Australian–American Fulbright Commission (RBG). JBM and AJN are funded by the Scottish Government RERAD. CC was the grateful recipient of a Dr Sue Newton Scholarship and an International Postgraduate Research Scholarship (IPRS) from the Australian Government via The University of Melbourne. PG is a Postdoctoral Fellow of the Fund for Scientific Research – Flanders (Belgium) (F.W.O. – Vlaanderen).
Funders:
Funding AgencyGrant Number
Australian Research CouncilDP0665230
Australian Academy of ScienceUNSPECIFIED
Australian–American Fulbright CommissionUNSPECIFIED
Scottish Government RERADUNSPECIFIED
University of MelbourneUNSPECIFIED
Fund for Scientific Research – Flanders (Belgium)UNSPECIFIED
Subject Keywords:Sperm coating protein-extracellular domain; SCP/TAPS; Activation-associated secreted proteins; Hookworms; Classification; Nomenclature; Bayesian inference; Venom allergen; Pathogenesis-related proteins
Issue or Number:4
Record Number:CaltechAUTHORS:20090804-100455850
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20090804-100455850
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:14784
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:07 Aug 2009 05:32
Last Modified:03 Oct 2019 00:52

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