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Study of blood flow impact on growth of thrombi using a multiscale model

Xu, Zhiliang and Chen, Nan and Shadden, Shawn C. and Marsden, Jerrold E. and Kamocka, Malgorzata M. and Rosen, Elliot D. and Alber, Mark (2009) Study of blood flow impact on growth of thrombi using a multiscale model. Soft Matter, 5 (4). pp. 769-779. ISSN 1744-683X.

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An extended multiscale model is introduced for studying the formation of platelet thrombi in blood vessels. The model describes the interplay between viscous, incompressible blood plasma, activated and non-activated platelets, as well as other blood cells, activating chemicals, fibrinogen and vessel walls. The macroscale dynamics of the blood flow is represented by the continuous submodel in the form of the Navier–Stokes equations. The microscale cell-cell interactions are described by the stochastic Cellular Potts Model (CPM). Simulations indicate that increase in flow rates leads to greater structural heterogeneity of the clot. As heterogeneous structural domains within the clot affect thrombus stability, understanding the factors influencing thrombus structure is of significant biomedical importance.

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Additional Information:© 2009 Royal Society of Chemistry. Received 21st July 2008, Accepted 3rd October 2008. First published as an Advance Article on the web 12th December 2008. This work was partially supported by NSF Grant DMS-0800612 to MA, ZX and NC and by NIH grant HL073750 to EDR.
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:14816
Deposited By: Tony Diaz
Deposited On:06 Aug 2009 22:54
Last Modified:27 Oct 2017 18:20

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