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Kidney damage in extracorporeal shock wave lithotripsy: a numerical approach for different shock profiles

Weinberg, Kerstin and Ortiz, Michael (2009) Kidney damage in extracorporeal shock wave lithotripsy: a numerical approach for different shock profiles. Biomechanics and Modeling in Mechanobiology, 8 (4). pp. 285-299. ISSN 1617-7959. https://resolver.caltech.edu/CaltechAUTHORS:20090808-142504866

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Abstract

In shock-wave lithotripsy—a medical procedure to fragment kidney stones—the patient is subjected to hypersonic waves focused at the kidney stone. Although this procedure is widely applied, the physics behind this medical treatment, in particular the question of how the injuries to the surrounding kidney tissue arise, is still under investigation. To contribute to the solution of this problem, two- and three-dimensional numerical simulations of a human kidney under shock-wave loading are presented. For this purpose a constitutive model of the bio-mechanical system kidney is introduced, which is able to map large visco-elastic deformations and, in particular, material damage. The specific phenomena of cavitation induced oscillating bubbles is modeled here as an evolution of spherical pores within the soft kidney tissue. By means of large scale finite element simulations, we study the shock-wave propagation into the kidney tissue, adapt unknown material parameters and analyze the resulting stress states. The simulations predict localized damage in the human kidney in the same regions as observed in animal experiments. Furthermore, the numerical results suggest that in first instance the pressure amplitude of the shock wave impulse (and not so much its exact time-pressure profile) is responsible for damaging the kidney tissue.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/s10237-008-0135-0DOIArticle
https://rdcu.be/b1cNQPublisherFree ReadCube access
ORCID:
AuthorORCID
Ortiz, Michael0000-0001-5877-4824
Additional Information:© 2009 Springer. Received: 2 November 2007 Accepted: 26 July 2008 Published online: 18 September 2008. The work was in part founded by the NIH grant #DK55674. The authors gratefully acknowledge the support.
Group:GALCIT
Funders:
Funding AgencyGrant Number
NIHDK55674
Subject Keywords:Kidney; Soft tissue; Injury; Damage; Large deformation; Constitutive model; Cavitation; Shock wave; Finite element analysis
Issue or Number:4
Record Number:CaltechAUTHORS:20090808-142504866
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20090808-142504866
Official Citation:Weinberg, K., Ortiz, M. Kidney damage in extracorporeal shock wave lithotripsy: a numerical approach for different shock profiles. Biomech Model Mechanobiol 8, 285 (2009). https://doi.org/10.1007/s10237-008-0135-0
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:14904
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:03 Sep 2009 17:12
Last Modified:04 Feb 2020 22:08

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