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Hyperpolarized ^1H NMR employing low γ nucleus for spin polarization storage

Chekmenev, Eduard Y. and Norton, Valerie A. and Weitekamp, Daniel P. and Bhattacharya, Pratip K. (2009) Hyperpolarized ^1H NMR employing low γ nucleus for spin polarization storage. Journal of the American Chemical Society, 131 (9). pp. 3164-3165. ISSN 0002-7863. PMCID PMC2662390. https://resolver.caltech.edu/CaltechAUTHORS:20090814-132951758

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Abstract

The PASADENA (parahydrogen and synthesis allow dramatically enhanced nuclear alignment)(1, 2) and DNP (Dynamic Nuclear Polarization)(3) methods efficiently hyperpolarize biologically relevant nuclei such as 1^H, (31)^P, (13)^C, (15)^N achieving signal enhancement by a factor of ~ 100000 on currently utilized MRI scanners. Recently, many groups have demonstrated the utility of hyperpolarized MR in biological systems using hyperpolarized (13)^C biomarkers with a relatively long spin lattice relaxation time T_1 on the order of tens of seconds.(4-7) Moreover, hyperpolarized (15)^N for biomedical MR has been proposed due to even longer spin lattice relaxations times.(8) An additional increase of up to tens of minutes in the lifetime of hyperpolarized agent in vivo could be achieved by using the singlet states of low gamma (γ) nuclei.(9) However, as NMR receptivity scales as γ^3 for spin 1/2 nuclei, direct NMR detection of low γ nuclei results in a lower signal-to-noise ratio compared to proton detection. While protons are better nuclei for detection, short spin lattice relaxation times prevent direct 1^H hyperpolarized MR in biomedical applications.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja809634uDOIArticle
http://pubs.acs.org/doi/full/10.1021/ja809634uPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662390/PubMed CentralArticle
Additional Information:© 2009 American Chemical Society. ACS AuthorChoice. Publication Date (Web): February 16, 2009. Received December 9, 2008. We thank Drs. Brian D. Ross and William H. Perman and the following for funding: NIH 1K99CA134749-01, R01 CA 122513, 1R21 CA118509, Rudi Schulte Research Institute, James G. Boswell Fellowship, AHA, American Brain Tumor Association, Beckman Institute, Tobacco Related Disease Research Program 16KT-0044, Prevent Cancer Foundation.
Funders:
Funding AgencyGrant Number
NIH1K99CA134749-01
NIHR01 CA 122513
NIH1R21 CA118509
Rudi Schulte Research InstituteUNSPECIFIED
James G. Boswell FellowshipUNSPECIFIED
American Brain Tumor AssociationUNSPECIFIED
Caltech Beckman InstituteUNSPECIFIED
California Tobacco Related Disease Research Program16KT-0044
Prevent Cancer FoundationUNSPECIFIED
Issue or Number:9
PubMed Central ID:PMC2662390
Record Number:CaltechAUTHORS:20090814-132951758
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20090814-132951758
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:15042
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:15 Aug 2009 22:10
Last Modified:03 Oct 2019 00:54

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