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Protein synthesis at synaptic sites on dendrites

Steward, Oswald and Schuman, Erin M. (2001) Protein synthesis at synaptic sites on dendrites. Annual Review of Neuroscience, 24 . pp. 299-325. ISSN 0147-006X. http://resolver.caltech.edu/CaltechAUTHORS:STEarn01

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Abstract

Studies over the past 20 years have revealed that gene expression in neurons is carried out by a distributed network of translational machinery. One component of this network is localized in dendrites, where polyribosomes and associated membranous elements are positioned beneath synapses and translate a particular population of dendritic mRNAs. The localization of translation machinery and mRNAs at synapses endows individual synapses with the capability to independently control synaptic strength through the local synthesis of proteins. The present review discusses recent studies linking synaptic plasticity to dendritic protein synthesis and mRNA trafficking and considers how these processes are regulated. We summarize recent information about how synaptic signaling is coupled to local translation and to the delivery of newly transcribed mRNAs to activated synaptic sites and how local translation may play a role in activity-dependent synaptic modification.


Item Type:Article
Additional Information:"Reprinted, with permission, from the Annual Review of Neuroscience, Volume 24 copyright 2001 by Annual Reviews, www.annualreviews.org" This work was supported by NIHNS12333 (OS), NIHNS37292, NIMHMH49176, and HHMI (EMS).
Subject Keywords:SYNAPTIC PLASTICITY; GENE EXPRESSION; HIPPOCAMPUS; LONG-TERM POTENTIATION; METABOTROPIC GLUTAMATE RECEPTORS; POSTSYNAPTIC MEMBRANE SPECIALIZATIONS; ROUGH ENDOPLASMIC-RETICULUM; MENTAL-RETARDATION PROTEIN; MESSENGER-RNA EXPRESSION; CENTRAL-NERVOUS-SYSTEM; DEVELOPING RAT-BRAIN; DEPENDENT LATE-PHASE; HIPPOCAMPAL-NEURONS
Record Number:CaltechAUTHORS:STEarn01
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:STEarn01
Alternative URL:http://dx.doi.org/10.1146/annurev.neuro.24.1.299
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1522
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 Jan 2006
Last Modified:26 Dec 2012 08:44

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