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A dynamic double helical band as a model for cardiac pumping

Grosberg, Anna and Gharib, Morteza (2009) A dynamic double helical band as a model for cardiac pumping. Bioinspiration and Biomimetics, 4 (2). 026003. ISSN 1748-3182. https://resolver.caltech.edu/CaltechAUTHORS:20090824-144225141

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Abstract

We address here, by means of finite-element computational modeling, two features of heart mechanics and, most importantly, their timing relationship: one of them is the ejected volume and the other is the twist of the heart. The corner stone of our approach is to take the double helical muscle fiber band as the dominant active macrostructure behind the pumping function. We show that this double helical model easily reproduces a physiological maximal ejection fraction of up to 60% without exceeding the limit on local muscle fiber contraction of 15%. Moreover, a physiological ejection fraction can be achieved independently of the excitation pattern. The left ventricular twist is also largely independent of the type of excitation. However, the physiological relationship between the ejection fraction and twist can only be reproduced with Purkinje-type excitation schemes. Our results indicate that the proper timing coordination between twist and ejection dynamics can be reproduced only if the excitation front originates in the septum region near the apex. This shows that the timing of the excitation is directly related to the productive pumping operation of the heart and illustrates the direction for possible bioinspired pump design.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1088/1748-3182/4/2/026003DOIUNSPECIFIED
http://www.iop.org/EJ/abstract/1748-3190/4/2/026003/PublisherUNSPECIFIED
http://stacks.iop.org/BB/4/026003PublisherUNSPECIFIED
Additional Information:Copyright © Institute of Physics and IOP Publishing Limited 2009. Received 29 July 2008, accepted for publication 14 May 2009 Published 28 May 2009. Print publication: Issue 2 (June 2009). We would like to thank Dr P Helm for providing the MRI images of the cardiac myofibrils.
Group:GALCIT
Issue or Number:2
Record Number:CaltechAUTHORS:20090824-144225141
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20090824-144225141
Official Citation:A dynamic double helical band as a model for cardiac pumping Anna Grosberg and Morteza Gharib 2009 Bioinspir. Biomim. 4 026003 (9pp) doi: 10.1088/1748-3182/4/2/026003
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:15284
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:09 Sep 2009 21:35
Last Modified:03 Oct 2019 00:56

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