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Mutation, specialization, and hypersensitivity in highly optimized tolerance

Zhou, Tong and Carlson, J. M. and Doyle, John (2002) Mutation, specialization, and hypersensitivity in highly optimized tolerance. Proceedings of the National Academy of Sciences of the United States of America, 99 (4). pp. 2049-2054. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:ZHOpnas02b

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Abstract

We introduce a model of evolution in which competing organisms are represented by percolation lattice models. Fitness is based on the number of occupied sites remaining after removing a cluster connected to a randomly selected site. High-fitness individuals arising through mutation and selection must trade off density versus robustness to loss, and are characterized by cellular barrier patterns that prevent large cascading losses to common disturbances. This model shows that Highly Optimized Tolerance (HOT), which links complexity to robustness in designed systems, arises naturally through Darwinian mechanisms. Although the model is a severe abstraction of biology, it produces a surprisingly wide variety of micro- and macroevolutionary features strikingly similar to real biological evolution.


Item Type:Article
Additional Information:Copyright © 2002 by the National Academy of Sciences Communicated by James S. Langer, University of California, Santa Barbara, CA, December 31, 2001 (received for review April 24, 2001) We thank Jeff Endelman, Carl Robert, and Deborah Fygenson for helpful discussions. This work was supported by the David and Lucile Packard Foundation, National Science Foundation Grant DMR-9813752, and the Electric Power Research Institute/Department of Defense through the Program on Interactive Complex Networks. Theoretical foundations for this work were developed in the Air Force Office of Scientific Research/Department of Defense Multidisciplinary University Research Initiative "Uncertainty Management in Complex Systems."
Subject Keywords:SOC, self-organized criticality; EOC, edge of chaos; HOT, Highly Optimized Tolerance
Issue or Number:4
Record Number:CaltechAUTHORS:ZHOpnas02b
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:ZHOpnas02b
Alternative URL:http://dx.doi.org/10.1073/pnas.261714399
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1529
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:26 Jan 2006
Last Modified:03 Jan 2018 19:32

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