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Location-Specific Cortical Activation Changes during Sleep after Training for Perceptual Learning

Yotsumoto, Yuko and Sasaki, Yuka and Chan, Patrick and Vasios, Christos E. and Bonmassar, Giorgio and Ito, Nozomi and Náñez, José E., Sr. and Shimojo, Shinsuke and Watanabe, Takeo (2009) Location-Specific Cortical Activation Changes during Sleep after Training for Perceptual Learning. Current Biology, 19 (15). pp. 1278-1282. ISSN 0960-9822. PMCID PMC2755500.

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Visual perceptual learning is defined as performance enhancement on a sensory task and is distinguished from other types of learning and memory in that it is highly specific for location of the trained stimulus. The location specificity has been shown to be paralleled by enhancement in functional magnetic resonance imaging (fMRI) signal in the trained region of V1 after visual training. Although recently the role of sleep in strengthening visual perceptual learning has attracted much attention, its underlying neural mechanism has yet to be clarified. Here, for the first time, fMRI measurement of human V1 activation was conducted concurrently with a polysomnogram during sleep with and without preceding training for visual perceptual learning. As a result of predetermined region-of-interest analysis of V1, activation enhancement during non-rapid-eye-movement sleep after training was observed specifically in the trained region of V1. Furthermore, improvement of task performance measured subsequently to the post-training sleep session was significantly correlated with the amount of the trained-region-specific fMRI activation in V1 during sleep. These results suggest that as far as V1 is concerned, only the trained region is involved in improving task performance after sleep.

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Additional Information:© 2009 Elsevier. Received 4 February 2009; revised 30 May 2009; accepted 1 June 2009. Published online: July 2, 2009. Available online 2 July 2009. This work was supported by the National Eye Institutes (R21EY018925, R01EY019466, and R01EY015980), the National Institutes of Health National Center for Research Resources (P41RR14075), the Mental Illness and Neuroscience Discovery (MIND) Institute, the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, the ERATO Shimojo Implicit Brain Function Project from Japan Science and Technology, and the Japan Society for the Promotion of Science. The authors thank Patrick Purdon and Leonardo Angelone for assistance in simultaneous EEG and fMRI measurements and Kristina Vissher and Aaron Seitz for helpful comments.
Funding AgencyGrant Number
Mental Illness and Neuroscience Discovery Institute (MIND)UNSPECIFIED
Athinoula A. Martinos Center for Biomedical ImagingUNSPECIFIED
Massachusetts General HospitalUNSPECIFIED
Harvard Medical SchoolUNSPECIFIED
ERATO Shimojo Implicit Brain Function ProjectUNSPECIFIED
Japan Society for the Promotion of Science (JSPS)UNSPECIFIED
Subject Keywords:SYSNEURO
Issue or Number:15
PubMed Central ID:PMC2755500
Record Number:CaltechAUTHORS:20090827-134422668
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:15362
Deposited By: Jason Perez
Deposited On:08 Sep 2009 16:32
Last Modified:03 Oct 2019 00:57

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