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Genomic control of patterning

Peter, Isabelle S. and Davidson, Eric H. (2009) Genomic control of patterning. International Journal of Developmental Biology, 53 (5-6). pp. 707-716. ISSN 0214-6282. PMCID PMC3967875. doi:10.1387/ijdb.072495ip.

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The development of multicellular organisms involves the partitioning of the organism into territories of cells of specific structure and function. The information for spatial patterning processes is directly encoded in the genome. The genome determines its own usage depending on stage and position, by means of interactions that constitute gene regulatory networks (GRNs). The GRN driving endomesoderm development in sea urchin embryos illustrates different regulatory strategies by which developmental programs are initiated, orchestrated, stabilized or excluded to define the pattern of specified territories in the developing embryo.

Item Type:Article
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URLURL TypeDescription CentralArticle
Peter, Isabelle S.0000-0003-3685-3147
Additional Information:© 2009 UBC Press. Published online: 5 March 2009. We thank Andrew Ransick for helpul discussion and critical reading of the manuscript. Research was funded by NIH grant HD37105; I.P. was supported by a fellowship from the Swiss National Science Foundation.
Funding AgencyGrant Number
Swiss National Science FoundationUNSPECIFIED
Subject Keywords:gene regulatory network, cis-regulatory module, network subcircuit, sea urchin, development
Issue or Number:5-6
PubMed Central ID:PMC3967875
Record Number:CaltechAUTHORS:20090828-231035403
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:15459
Deposited By: George Porter
Deposited On:11 Sep 2009 23:05
Last Modified:08 Nov 2021 23:19

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