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Mechanisms underlying the sensitivity of songbird forebrain neurons to temporal order

Lewicki, Michael S. and Konishi, Masakazu (1995) Mechanisms underlying the sensitivity of songbird forebrain neurons to temporal order. Proceedings of the National Academy of Sciences of the United States of America, 92 (12). pp. 5582-5586. ISSN 0027-8424. PMCID PMC41740.

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Neurons in the songbird forebrain area HVc (hyperstriatum ventrale pars caudale or high vocal center) are sensitive to the temporal structure of the bird's own song and are capable of integrating auditory information over a period of several hundred milliseconds. Extracellular studies have shown that the responses of some HVc neurons depend on the combination and temporal order of syllables from the bird's own song, but little is known about the mechanisms underlying these response properties. To investigate these mechanisms, we recorded intracellular responses to a set of auditory stimuli designed to assess the degree of dependence of the responses on temporal contest. This report provides evidence that HVc neurons encode information about temporal structure by using a variety of mechanisms including syllable-specific inhibition, excitatory postsynaptic potentials with a range of different time courses, and burst-firing nonlinearity. The data suggest that the sensitivity of HVc neurons to temporal combinations of syllables results from the interactions of several cells and does not arise in a single step from afferent inputs alone.

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Additional Information:Copyright © 1995 by the National Academy of Sciences. Contributed by Masakazu Konishi, February 22, 1995. We thank James Mazer, David Perkel, and Allison Doupe for helpful comments on the manuscript. This work was supported by a National Institutes of Health research training grant and an Engineering Research Center fellowship. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
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Engineering Research Center at CaltechUNSPECIFIED
Issue or Number:12
PubMed Central ID:PMC41740
Record Number:CaltechAUTHORS:LEWpnas95b
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1556
Deposited By: Tony Diaz
Deposited On:30 Jan 2006
Last Modified:02 Oct 2019 22:44

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