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Methods for unveiling cryptic microbial partnerships in nature

Orphan, Victoria J. (2009) Methods for unveiling cryptic microbial partnerships in nature. Current Opinion in Microbiology, 12 (3). pp. 231-237. ISSN 1369-5274. https://resolver.caltech.edu/CaltechAUTHORS:20090909-131707316

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Abstract

Syntrophy and mutualism play a central role in carbon and nutrient cycling by microorganisms. Yet our ability to recognize these partnerships in nature or to effectively study their behavior in culture has been hindered by the inherent interdependence of syntrophic associations, their dynamic behavior, and their frequent existence at thermodynamic limits. Now solutions to these challenges are emerging in new methodologies. These include: comparative metagenomics and transcriptomics; discovery-based methods such as Magneto-FISH; and metabolic substrate tracking using stable isotopes coupled either with density gradient separation (SIP) or with FISH-SIMS. These novel approaches are redefining the way we study microbial mutualism and are making intimate microbial associations accessible to both identification and characterization in their native habitats.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.mib.2009.04.003DOIArticle
ORCID:
AuthorORCID
Orphan, Victoria J.0000-0002-5374-6178
Additional Information:Copyright © 2009 Elsevier. Available online 15 May 2009. I thank A Dekas and A Pernthaler for contributing the Magneto-FISH and nanoSIMS images used in this review. I am also grateful to S Goffredi and D Newman for constructive comments. Research by VJO included in this review was supported by grants from the Gordon and Betty Moore Foundation, Davidow Research Fund, and National Science Foundation (MCB-0348492).
Funders:
Funding AgencyGrant Number
Gordon and Betty Moore FoundationUNSPECIFIED
Davidow Research Fund, CaltechUNSPECIFIED
NSFMCB-0348492
Issue or Number:3
Record Number:CaltechAUTHORS:20090909-131707316
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20090909-131707316
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:15701
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:14 Sep 2009 21:09
Last Modified:03 Oct 2019 01:01

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