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Self-powered microfluidic chips for multiplexed protein assays from whole blood

Qin, Lidong and Vermesh, Ophir and Shi, Qihui and Heath, James R. (2009) Self-powered microfluidic chips for multiplexed protein assays from whole blood. Lab on a Chip, 9 (14). pp. 2016-2020. ISSN 1473-0197. PMCID PMC3651861.

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We report herein on a self-powered, self-contained microfluidic-based chip designed to separate plasma from whole blood, and then execute an assay of a multiplexed panel of plasma biomarker proteins. The power source is based upon a chemical reaction that is catalytically triggered by the push of a button on the chip. We demonstrate assays of a dozen blood-based protein biomarkers using this automated, self-contained device. This platform can potentially permit high throughput, accurate, multiplexed blood diagnostic measurements in remote locations and by minimally trained individuals.

Item Type:Article
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URLURL TypeDescription CentralArticle
Heath, James R.0000-0001-5356-4385
Additional Information:© Royal Society of Chemistry 2009. Received 27th November 2008, Accepted 25th March 2009. First published on the web 16th April 2009. We would like to thank Dr. Rong Fan, Habib Ahmad, and Ke Xu for helpful discussions, and for providing assistance with certain aspects of device fabrication. This work was funded by the National Cancer Institute grant no. 5U54 CA119347 (J.R.H., P.I.), by the Institute for Collaborative Biotechnologies through grant DAAD19-03-D-0004 from the US Army Research Office, and also by the Jean Perkins Foundation.
Funding AgencyGrant Number
National Cancer Institute5U54 CA119347
Army Research Office (ARO)DAAD19-03-D-0004
Jean Perkins FoundationUNSPECIFIED
Issue or Number:14
PubMed Central ID:PMC3651861
Record Number:CaltechAUTHORS:20090910-091059453
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:15716
Deposited By: George Porter
Deposited On:07 Oct 2009 22:16
Last Modified:23 Dec 2019 17:18

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