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Parietal Reach Region Encodes Reach Depth Using Retinal Disparity and Vergence Angle Signals

Bhattacharyya, Rajan and Musallam, Sam and Andersen, Richard A. (2009) Parietal Reach Region Encodes Reach Depth Using Retinal Disparity and Vergence Angle Signals. Journal of Neurophysiology, 102 (2). pp. 805-816. ISSN 0022-3077. PMCID PMC2724352. doi:10.1152/jn.90359.2008. https://resolver.caltech.edu/CaltechAUTHORS:20090911-153601751

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PDF (Figure S1 – Disparity and Vergence Angle Sampling for Coupled Reach Targets in Experiment 1) - Supplemental Material
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PDF (Figure S2 – Disparity and Vergence Angle Sampling for Decoupled Reach Targets in Experiment 2) - Supplemental Material
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PDF (Figure S3 – Target sampling for Index A, calculating modulation by reach target disparity and fixation depth) - Supplemental Material
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PDF (Figure S4 – Target sampling for Index B, calculating modulation by vergence angle at constant reach target disparity) - Supplemental Material
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PDF (Figure S5 – Disparity tuning responses during cue, planning and movement periods) - Supplemental Material
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PDF (Figure S6 – Example of Complex disparity tuning from coupled reach targets viewed at 13° vergence angle) - Supplemental Material
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PDF (Figure S7 – Cue period DTI) - Supplemental Material
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PDF (FIGURE S8 – VTI from experiment 1) - Supplemental Material
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PDF (Figure S9 – Histogram of difference in tuning indices (Index A-Index B) from experiment 2 (n=137)) - Supplemental Material
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PDF (Table S1 - Supplemental Figure Legends, Tables, and Methods) - Supplemental Material
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Abstract

Performing a visually guided reach requires the ability to perceive the egocentric distance of a target in three-dimensional space. Previous studies have shown that the parietal reach region (PRR) encodes the two-dimensional location of frontoparallel targets in an eye-centered reference frame. To investigate how a reach target is represented in three dimensions, we recorded the spiking activity of PRR neurons from two rhesus macaques trained to fixate and perform memory reaches to targets at different depths. Reach and fixation targets were configured to explore whether neural activity directly reflects egocentric distance as the amplitude of the required motor command, which is the absolute depth of the target, or rather the relative depth of the target with reference to fixation depth. We show that planning activity in PRR represents the depth of the reach target as a function of disparity and fixation depth, the spatial parameters important for encoding the depth of a reach goal in an eye centered reference frame. The strength of modulation by disparity is maintained across fixation depth. Fixation depth gain modulates disparity tuning while preserving the location of peak tuning features in PRR neurons. The results show that individual PRR neurons code depth with respect to the fixation point, that is, in eye centered coordinates. However, because the activity is gain modulated by vergence angle, the absolute depth can be decoded from the population activity.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1152/jn.90359.2008DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc2724352/PubMed CentralArticle
ORCID:
AuthorORCID
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2009 by the The American Physiological Society. Submitted 12 March 2008; accepted in final form 10 May 2009. First published May 13, 2009; doi:10.1152/jn.90359.2008 This work was funded by National Institutes of Health and Office of Naval Research. We thank G. Mulliken, E. Hwang, and H. Cui, for helpful comments on the manuscript; Z. Nadasdy for useful discussions; K. Pejsa, N. Sammons, L. Martel, J. Baer, and C. Lindsell for help with animal handling and veterinary assistance; V. Shcherbatyuk for computer support; T. Yao for administrative assistance; and R. Panagua and M. Walsh for laboratory equipment construction. We also thank the reviewers for comments and suggestions.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
Issue or Number:2
PubMed Central ID:PMC2724352
DOI:10.1152/jn.90359.2008
Record Number:CaltechAUTHORS:20090911-153601751
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20090911-153601751
Official Citation:Rajan Bhattacharyya, Sam Musallam, and Richard A. Andersen Parietal Reach Region Encodes Reach Depth Using Retinal Disparity and Vergence Angle Signals J Neurophysiol 102: 805-816, 2009. First published doi:10.1152/jn.90359.2008
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:15807
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:07 Oct 2009 23:08
Last Modified:08 Nov 2021 23:22

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