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Selective uptake of multi-walled carbon nanotubes by tumor macrophages in a murine glioma model

VanHandel, Michelle and Alizadeh, Darya and Zhang, Leying and Kateb, Babak and Bronikowski, Michael and Manohara, Harish and Badie, Behnam (2009) Selective uptake of multi-walled carbon nanotubes by tumor macrophages in a murine glioma model. Journal of Neuroimmunology, 208 (1-2). pp. 3-9. ISSN 0165-5728.

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Carbon nantotubes (CNTs) are emerging as a new family of nanovectors for drug and gene delivery into biological systems. To evaluate potential application of this technology for brain tumor therapy, we, studied uptake and toxicity of multi-walled CNTs (MWCNTs) in the GL261 murine intracranial glioma model. Within 24 h of a single intratumoral injection of labeled MWCNTs (5 µg), nearly 10-20% of total cells demonstrated CNT internalization. Most CNT uptake, however, occurred by tumor-associated macrophages (MP), which accounted for most (75%) MWCNT-positive cells. Within 24 h of injection, nearly 30% of tumor MP became MWCNT-positive. Despite a transient increase in inflammatory cell infiltration into both normal and tumor-bearing brains following MWCNT injection, no significant toxicity was noted in mice, and minor changes in tumor cytokine expression were observed. This study suggests that MWCNTs could potentially be used as a novel and non-toxic vehicle for targeting MP in brain tumors.

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Additional Information:© 2008 Elsevier B.V. Received 8 September 2008. Received in revised form 12 December 2008. Accepted 12 December 2008. This work was supported by the American Cancer Society Research Scholar Grant (RSG-03-142-01-CNE). The City of Hope Flow Cytometry Core was equipped in part through funding provided by ONR N00014-02-1 0958, DOD 1435-04-03GT-73134, and NSF DBI-9970143. The nanotube synthesis work described in this publication was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (NASA).
Funding AgencyGrant Number
American Cancer SocietyRSG-03-142-01-CNE
Office of Naval Research (ONR)N0001402-1 0958
Department of Defense1435-04-03G17-73134
Subject Keywords:Carbon nanotubes; Nanotechnology; Glioma; Immunotherapy; Nanoparticles; Macrophage; Microglia; Brain tumor
Record Number:CaltechAUTHORS:20090914-144444121
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:15843
Deposited By: Tony Diaz
Deposited On:16 Sep 2009 18:31
Last Modified:07 Aug 2017 17:43

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