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The biological restoration of central nervous system architecture and function: Part 2-emergence of the realization of adults neurogenesis

Farin, Azadeh and Liu, Charles Y. and Langmoen, Iver A. and Apuzzo, Michael L. J. (2009) The biological restoration of central nervous system architecture and function: Part 2-emergence of the realization of adults neurogenesis. Neurosurgery, 64 (4). pp. 582-600. ISSN 0148-396X. https://resolver.caltech.edu/CaltechAUTHORS:20090915-150019754

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Abstract

BEFORE THE 1960s, adult mammalian neurogenesis was conceptually unimaginable. Despite 45 years of observations supporting this revolutionary phenomenon, many scientists rejected this notion until irrefutable evidence provided at the end of the 20th century established that lifelong neuronal generation occurs in the adult mammalian brain. Today, in place of being viewed as a nonregenerative dormant organ, a defining characteristic of the brain is its plasticity, or capacity to undergo environment- and activity-related cytophysiological remodeling. In this second article in a 5-part series on stem cells, we trace the milestones that gave birth to a new era in neuroscience: the realization of adult mammalian neurogenesis.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1227/01.NEU.0000343539.15177.D1DOIUNSPECIFIED
http://journals.lww.com/neurosurgery/pages/articleviewer.aspx?year=2009&issue=04000&article=00009&type=abstractPublisherUNSPECIFIED
Additional Information:© 2009 by the Congress of Neurological Surgeons. We gratefully acknowledge James C. Wald, Esq., for assistance with the illustrations.
Issue or Number:4
Record Number:CaltechAUTHORS:20090915-150019754
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20090915-150019754
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:15863
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:16 Sep 2009 18:43
Last Modified:03 Oct 2019 01:04

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