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Decision by committee: new light on the CD4/CD8-lineage choice

Rothenberg, Ellen V. (2009) Decision by committee: new light on the CD4/CD8-lineage choice. Immunology and Cell Biology, 87 (2). pp. 109-112. ISSN 0818-9641. doi:10.1038/icb.2008.100.

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The essence of a developmental decision is to convert a temporary difference between two cells, for example in their current exposure to environmental signals, into a long-term, irreversible difference in phenotype and function. For years, one of the most striking examples of this mechanism has been the choice of developing T cells between maturation in the CD4+ CD8- lineages or the CD4- CD8+ lineages, but the molecular mechanisms underpinning this decision have remained poorly understood. Three elegant studies published recently in Nature Immunology establish a sophisticated hierarchy of transcriptional regulators in which expression of triggering factors is followed by expression of enforcement factors, including Thpok and Runx3, to determine CD4/CD8-lineage choice.

Item Type:Article
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URLURL TypeDescription DOIArticle
Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 2009 Australasian Society for Immunology. Published online 16 December 2008.
Issue or Number:2
Record Number:CaltechAUTHORS:20090922-094135817
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:15989
Deposited By: Tony Diaz
Deposited On:24 Sep 2009 22:48
Last Modified:08 Nov 2021 23:24

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