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Improvement of metal and tissue adhesion on surface-modified parylene C

Wahjudi, Paulin N. and Oh, Jin H. and Salman, Salam O. and Seabold, Jason A. and Rodger, Damien C. and Tai, Yu-Chong and Thompson, Mark E. (2009) Improvement of metal and tissue adhesion on surface-modified parylene C. Journal of Biomedical Materials Research Part A, 89a (1). pp. 206-214. ISSN 1549-3296.

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A general method for chemical surface functionalization of parylene C [PC, (para-CH_2-C_6H_3Cl-CH_2-)_n] films is reported. Friedel-Crafts acylation is used to activate the surface of the PC film, and the resulting carbonyl groups are then used to form a range of different organic functional groups to the surface of the parylene film, including alcohol, imine, thiol, phthalimide, amine, and maleimide. The presence of these functional groups on the parylene surface was confirmed by Fourier transform infrared spectroscopy. Static water drop contact angle measurements were also used to demonstrate the changes in hydrophilicity of the PC film surface, consistent with each of the surface modifications. Enhanced metal (gold) adhesion was achieved by anchoring a thiol group onto the acylated surface of PC film. Acylation of parylene with 2-chloropropionyl chloride gave a surface bound chloropropionyl group. Grafting of poly-N-isopropylacrylamide (pNIPAM) onto the chloropropionyl substituted PC film via atom transfer radical polymerization (ATRP) was carried out. The grafted pNIPAM on the parylene surface leads to temperature-dependent cellular tissue adhesion on the PC film

Item Type:Article
Related URLs:
URLURL TypeDescription
Rodger, Damien C.0000-0002-1583-5946
Tai, Yu-Chong0000-0001-8529-106X
Thompson, Mark E.0000-0002-7764-4096
Additional Information:© 1999-2009 John Wiley & Sons, Inc. Received: 26 April 2007; Revised: 4 December 2007; Accepted: 6 December 2007. We acknowledge Dr. Simona Garon for help with the gold deposition. Contract grant sponsor: Biomimetics Microelectronic System National Science Foundation-Engineering Research Center; contract grant number: EEC-0310723 Contract grant sponsors: National Science Foundation Research Experience for Undergraduate in Solid State Chemistry and University of Southern California Research Experience for Undergraduate
Funding AgencyGrant Number
National Science FoundationEEC-0310723
Subject Keywords:parylene; surface modification; Friedel-Crafts acylation; poly-N-isopropylacrylamide; atom-transfer radical polymerization; cell adhesion
Issue or Number:1
Record Number:CaltechAUTHORS:20090922-184821468
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:16000
Deposited By: Joy Painter
Deposited On:24 Sep 2009 15:51
Last Modified:09 Mar 2020 13:19

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