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Emerging new paradigms for ABCG transporters

Tarr, Paul T. and Tarling, Elizabeth J. and Bojanic, Dragana D. and Edwards, Peter A. and Baldán, Ángel (2009) Emerging new paradigms for ABCG transporters. Biochimica et Biophysica Acta, 1791 (7). pp. 584-593. ISSN 0167-4889.

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Every cell is separated from its external environment by a lipid membrane. Survival depends on the regulated and selective transport of nutrients, waste products and regulatory molecules across these membranes, a process that is often mediated by integral membrane proteins. The largest and most diverse of these membrane transport systems is the ATP binding cassette (ABC) family of membrane transport proteins. The ABC family is a large evolutionary conserved family of transmembrane proteins (> 250 members) present in all phyla, from bacteria to Homo sapiens, which require energy in the form of ATP hydrolysis to transport substrates against concentration gradients. In prokaryotes the majority of ABC transporters are involved in the transport of nutrients and other macromolecules into the cell. In eukaryotes, with the exception of the cystic fibrosis transmembrane conductance regulator (CFTR/ABCC7), ABC transporters mobilize substrates from the cytoplasm out of the cell or into specific intracellular organelles. This review focuses on the members of the ABCG subfamily of transporters, which are conserved through evolution in multiple taxa. As discussed below, these proteins participate in multiple cellular homeostatic processes, and functional mutations in some of them have clinical relevance in humans.

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Additional Information:© 2009 Elsevier. Received 17 December 2008; revised 13 January 2009; accepted 13 January 2009. Available online 22 January 2009. The authors apologize to those investigators whose papers had to be omitted due to space limitations. We are indebted to Dr. Larry Zipursky and members of the Zipursky lab at UCLA for their invaluable help with the experiments in Drosophila. We also thank the members of the Edwards lab for critical reading of the manuscript. This work was supported in part by National Institutes of Health Grants NIH30568 and NIH68445 (to P.A.E.), a grant from the Laubisch Fund (to P.A.E.), and a grant from Pfizer, Inc. (to P.A.E.).
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Subject Keywords:ABC transporter; ABCG; Sterol transporter; Multidrug resistance; Sitosterolemia; Atherosclerosis
Issue or Number:7
Record Number:CaltechAUTHORS:20090923-092303147
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:16004
Deposited By: Jason Perez
Deposited On:23 Sep 2009 18:55
Last Modified:03 Oct 2019 01:06

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