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The WIGGUM gene is required for proper regulation of floral meristem size in Arabidopsis

Running, Mark P. and Fletcher, Jennifer C. and Meyerowitz, Elliot M. (1998) The WIGGUM gene is required for proper regulation of floral meristem size in Arabidopsis. Development, 125 (14). pp. 2545-2553. ISSN 0950-1991.

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The study of cell division control within developing tissues is central to understanding the processes of pattern formation. The floral meristem of angiosperms gives rise to floral organs in a particular number and pattern. Despite its critical role, little is known about how cell division is controlled in the floral meristem, and few genes involved have been identified. We describe the phenotypic effects of mutations in WIGGUM, a gene required for control of cell proliferation in the floral and apical meristem of Arabidopsis thaliana. wiggum flowers contain more organs, especially sepals and petals, than found in wild-type flowers. This organ number phenotype correlates with specific size changes in the early floral meristem, preceding organ initiation. Genetic studies suggest that WIGGUM acts on a similar process but in a separate pathway than the CLAVATA1 and CLAVATA3 genes in meristem size regulation, and reveal interactions with other genes affecting meristem structure and identity. Analysis of double mutant phenotypes also reveals a role for WIGGUM in apical meristem function. We propose that WIGGUM plays a role in restricting cell division relative to cellular differentiation in specific regions of the apical and floral meristems.

Item Type:Article
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Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 1998 Company of Biologists. Accepted 8 May; published on WWW 23 June 1998. We thank Detlef Weigel for providing the wig-1 mutant, and Adam Readhead and Jane Wei for assistance in the mapping of WIG. We thank Pat Koen for assistance with the scanning electron microscope, and Xuemei Chen, Jian Hua, Steven Jacobsen, Carolyn Ohno, Preeya Puangsomlee, Jose-Luis Reichmann, Robert Sablowski, Robert Williams, and Eva Ziegelhoffer for comments on the manuscript. This work was supported by NSF-MCB grant no. 9603821 to E. M. M. and NIH postdoctoral grant no. GM17868 to J. C. F. M. P. R was a Howard Hughes Predoctoral Fellow. This article is dedicated to the memory of Rebecca Rothenberg.
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:Arabidopsis; WIGGUM (WIG); Floral meristem; Flower development; Pattern formation
Issue or Number:14
Record Number:CaltechAUTHORS:20090925-105818247
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Official Citation:The WIGGUM gene is required for proper regulation of floral meristem size in Arabidopsis M.P. Running, J.C. Fletcher, E.M. Meyerowitz Development 1998 125: 2545-2553
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:16059
Deposited By: George Porter
Deposited On:05 Oct 2009 16:20
Last Modified:03 Oct 2019 01:07

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