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Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations

Weissman­, Irving L. and Anderson­, David J. and Gage­, Fred (2001) Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations. Annual Review of Cell and Developmental Biology, 17 . pp. 387-403. ISSN 1081-0706. doi:10.1146/annurev.cellbio.17.1.387.

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Multipotent stem cells are clonal cells that self-renew as well as differentiate to regenerate adult tissues. Whereas stem cells and their fates are known by unique genetic marker studies, the fate and function of these cells are best studied by their prospective isolation. This review is about the properties of various highly purified tissue-specific multipotent stem cells and purified oligolineage progenitors. We contend that unless the stem or progenitor cells in question have been purified to near homogeneity, one cannot know whether their generation of expected (or unexpected) progeny is a property of a known cell type. It is interesting that in the hematopoietic system the only long-term self-renewing cells in the stem and progenitors pool are the hematopoietic stem cells. This fact is discussed in the context of normal and leukemic hematopoiesis.

Item Type:Article
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Anderson­, David J.0000-0001-6175-3872
Additional Information:© 2001 by Annual Reviews.
Subject Keywords:stem cells, progenitors, multipotent, tra
Record Number:CaltechAUTHORS:WEIarcdb01
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Official Citation:Stem and Progenitor Cells: Origins, Phenotypes, Lineage Commitments, and Transdifferentiations. Irving L. Weissman David J. Anderson Fred Gage. Annual Review of Cell and Developmental Biology 2001 17:1, 387-403; doi: 10.1146/annurev.cellbio.17.1.387
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1621
Deposited By: Tony Diaz
Deposited On:07 Feb 2006
Last Modified:08 Nov 2021 19:11

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