Schultz, Brian E. and Chan, Sunney I. (2001) Structures and proton-pumping strategies of mitochondrial respiratory enzymes. Annual Review of Biophysics and Biomolecular Structure, 30 . pp. 23-65. ISSN 1056-8700. doi:10.1146/annurev.biophys.30.1.23. https://resolver.caltech.edu/CaltechAUTHORS:SCHarbbs01
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Abstract
Enzymes of the mitochondrial respiratory chain serve as proton pumps, using the energy made available from electron transfer reactions to transport protons across the inner mitochondrial membrane and create an electrochemical gradient used for the production of ATP. The ATP synthase enzyme is reversible and can also serve as a proton pump by coupling ATP hydrolysis to proton translocation. Each of the respiratory enzymes uses a different strategy for performing proton pumping. In this work, the strategies are described and the structural bases for the action of these proteins are discussed in light of recent crystal structures of several respiratory enzymes. The mechanisms and efficiency of proton translocation are also analyzed in terms of the thermodynamics of the substrate transformations catalyzed by these enzymes.
Item Type: | Article | ||||||
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Additional Information: | "Reprinted, with permission, from the Annual Review of Biophysics and Biomolecular Structure, Volume 30 copyright 2001 by Annual Reviews, www.annualreviews.org" We would like to thank Tina Iverson for assistance in the preparation of several figures presented in this work and for many helpful discussions. | ||||||
Subject Keywords: | CRYSTAL STRUCTURES; FREE ENERGY TRANSDUCTION; MITOCHONDRION; REDOX LINKAGE; RESPIRATORY ELECTRON TRANSPORT CHAIN; CYTOCHROME-C-OXIDASE; NADH-UBIQUINONE OXIDOREDUCTASE; BOVINE HEART-MITOCHONDRIA; ELECTRON-PARAMAGNETIC-RESONANCE; COLI FUMARATE REDUCTASE; 2 INDEPENDENT PATHWAYS; STEADY-STATE KINETICS; STRETCHING RAMAN BAND; IRON SULFUR PROTEINS; COMPLEX-I | ||||||
DOI: | 10.1146/annurev.biophys.30.1.23 | ||||||
Record Number: | CaltechAUTHORS:SCHarbbs01 | ||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:SCHarbbs01 | ||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
ID Code: | 1623 | ||||||
Collection: | CaltechAUTHORS | ||||||
Deposited By: | Tony Diaz | ||||||
Deposited On: | 09 Feb 2006 | ||||||
Last Modified: | 08 Nov 2021 19:11 |
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