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Structures and proton-pumping strategies of mitochondrial respiratory enzymes

Schultz, Brian E. and Chan, Sunney I. (2001) Structures and proton-pumping strategies of mitochondrial respiratory enzymes. Annual Review of Biophysics and Biomolecular Structure, 30 . pp. 23-65. ISSN 1056-8700. https://resolver.caltech.edu/CaltechAUTHORS:SCHarbbs01

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Abstract

Enzymes of the mitochondrial respiratory chain serve as proton pumps, using the energy made available from electron transfer reactions to transport protons across the inner mitochondrial membrane and create an electrochemical gradient used for the production of ATP. The ATP synthase enzyme is reversible and can also serve as a proton pump by coupling ATP hydrolysis to proton translocation. Each of the respiratory enzymes uses a different strategy for performing proton pumping. In this work, the strategies are described and the structural bases for the action of these proteins are discussed in light of recent crystal structures of several respiratory enzymes. The mechanisms and efficiency of proton translocation are also analyzed in terms of the thermodynamics of the substrate transformations catalyzed by these enzymes.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1146/annurev.biophys.30.1.23["eprint_fieldopt_related_url_type_DOI" not defined]UNSPECIFIED
ORCID:
AuthorORCID
Chan, Sunney I.0000-0002-5348-2723
Additional Information:"Reprinted, with permission, from the Annual Review of Biophysics and Biomolecular Structure, Volume 30 copyright 2001 by Annual Reviews, www.annualreviews.org" We would like to thank Tina Iverson for assistance in the preparation of several figures presented in this work and for many helpful discussions.
Subject Keywords:CRYSTAL STRUCTURES; FREE ENERGY TRANSDUCTION; MITOCHONDRION; REDOX LINKAGE; RESPIRATORY ELECTRON TRANSPORT CHAIN; CYTOCHROME-C-OXIDASE; NADH-UBIQUINONE OXIDOREDUCTASE; BOVINE HEART-MITOCHONDRIA; ELECTRON-PARAMAGNETIC-RESONANCE; COLI FUMARATE REDUCTASE; 2 INDEPENDENT PATHWAYS; STEADY-STATE KINETICS; STRETCHING RAMAN BAND; IRON SULFUR PROTEINS; COMPLEX-I
Record Number:CaltechAUTHORS:SCHarbbs01
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:SCHarbbs01
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1623
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Feb 2006
Last Modified:02 Oct 2019 22:45

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