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Effect of Fiber Geometry on Pulsatile Pumping and Energy Expenditure

Grosberg, Anna and Gharib, Morteza and Kheradvar, Arash (2009) Effect of Fiber Geometry on Pulsatile Pumping and Energy Expenditure. Bulletin of Mathematical Biology, 71 (7). pp. 1580-1598. ISSN 0092-8240. https://resolver.caltech.edu/CaltechAUTHORS:20091013-093452979

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Abstract

Myocardial fiber orientation is a topic that has recently received much attention in connection with cardiac pumping function. The twisting motion of the cardiac base to apex can be a direct result of this geometric orientation of these fibers. One important question that has not been addressed yet is whether there is any relationship between the contractile energy expenditure and the geometric orientation of myocardial fibers. In the present work, we study the effect of contractile fiber orientation on pumping function. We particularly compare the effect of fiber geometry on ejection fraction, and on the energy required for contraction in both cylindrical and half-ellipsoid shell models. The analytical models we used signify the importance of twisting motion in minimizing the energy required to generate certain ejection fraction. Indeed, we quantified that if the angle of contractile fibers is appropriate for the shape and the size of the pump, twisting scheme can tremendously reduce the energy requirement for pumping.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/s11538-009-9414-xDOIUNSPECIFIED
http://www.springerlink.com/content/5416p020pw6q6237/PublisherUNSPECIFIED
Additional Information:© Society for Mathematical Biology 2009. Received: 28 August 2008 / Accepted: 16 February 2009 / Published online: 14 March 2009.
Group:GALCIT
Subject Keywords:Ventricular pumping; Analytical model; Cardiac twist
Issue or Number:7
Record Number:CaltechAUTHORS:20091013-093452979
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20091013-093452979
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:16316
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:19 Oct 2009 00:23
Last Modified:03 Oct 2019 01:09

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