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A biodegradable filament for controlled drug delivery

Mack, Brendan C. and Wright, Kenneth W. and Davis, Mark E. (2009) A biodegradable filament for controlled drug delivery. Journal of Controlled Release, 139 (3). pp. 205-211. ISSN 0168-3659. doi:10.1016/j.jconrel.2009.06.020. https://resolver.caltech.edu/CaltechAUTHORS:20091125-114131522

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Abstract

Biodegradable filaments (diameters of 250–300 μm) for the controlled delivery of dexamethasone or levofloxacin are described. Filaments are prepared by wet-spinning solutions of poly(lactide-co-glycolide) (PLGA) and drug dissolved in dimethyl sulfoxide (DMSO) into a coagulation bath of water. Compositional analyses of the filaments by independent measurements of drug, DMSO, water, and polymer give drug loadings up to 40% of filament mass and drug retention (drug in filament per drug in solution) greater than 40%. Drug release kinetics, and thermal and mechanical properties, of the filaments are reported. Three filaments with levofloxacin contents of 46 ± 2, 85 ± 4, and 36 ± 2 μg/cm (denoted 506-L1, 506-L2, and 506-L3, respectively) are implanted in the conjunctiva of New Zealand white rabbits. The time dependent, in-vivo tear concentrations of levofloxacin from filament implants in New Zealand white rabbit eyes are in general agreement with the results from the in-vitro release profiles, with one of the filaments (506-L1) showing effective levels of levofloxacin in the tears for 6 days. The filaments are generally well tolerated by the rabbits. Filament failure occurs at 6–8 days within the rabbit eyes, essentially the same time to failure observed from in-vitro mechanical properties testing results.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.jconrel.2009.06.020DOIUNSPECIFIED
ORCID:
AuthorORCID
Davis, Mark E.0000-0001-8294-1477
Additional Information:© 2009 Elsevier. Received 26 March 2009; accepted 22 June 2009. Available online 28 June 2009. Supplementary data associated with this article can be found, in the online version, at doi:10.1016/j.jconrel.2009.06.020.
Subject Keywords:Drug containing filament; Wet-spinning; Ophthalmic; Mechanical properties; Poly(lactide-co-glycolide)
Issue or Number:3
DOI:10.1016/j.jconrel.2009.06.020
Record Number:CaltechAUTHORS:20091125-114131522
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20091125-114131522
Official Citation:Brendan C. Mack, Kenneth W. Wright, Mark E. Davis, A biodegradable filament for controlled drug delivery, Journal of Controlled Release, Volume 139, Issue 3, 3 November 2009, Pages 205-211, ISSN 0168-3659, DOI: 10.1016/j.jconrel.2009.06.020. (http://www.sciencedirect.com/science/article/B6T3D-4WMM7C8-4/2/b75d22e36271abe9b6cc01ca8c5b0318)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:16811
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:04 Dec 2009 18:31
Last Modified:08 Nov 2021 23:30

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