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Cytokines and CNS Development

Deverman, Benjamin E. and Patterson, Paul H. (2009) Cytokines and CNS Development. Neuron, 64 (1). pp. 61-78. ISSN 0896-6273.

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Cytokines are pleotrophic proteins that coordinate the host response to infection as well as mediate normal, ongoing signaling between cells of nonimmune tissues, including the nervous system. As a consequence of this dual role, cytokines induced in response to maternal infection or prenatal hypoxia can profoundly impact fetal neurodevelopment. The neurodevelopmental roles of individual cytokine signaling pathways are being elucidated through gain- and loss-of-function studies in cell culture and model organisms. We review this work with a particular emphasis on studies where cytokines, their receptors, or components of their signaling pathways have been altered in vivo. The extensive and diverse requirements for properly regulated cytokine signaling during normal nervous system development revealed by these studies sets the foundation for ongoing and future work aimed at understanding how cytokines induced normally and pathologically during critical stages of fetal development alter nervous system function and behavior later in life.

Item Type:Article
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Deverman, Benjamin E.0000-0002-6223-9303
Additional Information:© 2009 Elsevier Inc. Available online 14 October 2009. Experiments described from the authors’ laboratory were funded by the NINDS and the McGrath Foundation. B.E.D. is supported by a fellowship from the California Institute for Regenerative Medicine.
Funding AgencyGrant Number
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
McGrath FoundationUNSPECIFIED
California Institute for Regenerative Medicine (CIRM)UNSPECIFIED
Issue or Number:1
Record Number:CaltechAUTHORS:20091125-143601263
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:16820
Deposited By: Tony Diaz
Deposited On:05 Jan 2010 17:30
Last Modified:03 Mar 2020 13:01

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