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Brain Control of Movement Execution Onset Using Local Field Potentials in Posterior Parietal Cortex

Hwang, Eun Jung and Andersen, Richard A. (2009) Brain Control of Movement Execution Onset Using Local Field Potentials in Posterior Parietal Cortex. Journal of Neuroscience, 29 (45). pp. 14363-14370. ISSN 0270-6474. PMCID PMC2805702. doi:10.1523/JNEUROSCI.2081-09.2009. https://resolver.caltech.edu/CaltechAUTHORS:20091210-083246641

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Abstract

The precise control of movement execution onset is essential for safe and autonomous cortical motor prosthetics. A recent study from the parietal reach region (PRR) suggested that the local field potentials (LFPs) in this area might be useful for decoding execution time information because of the striking difference in the LFP spectrum between the plan and execution states (Scherberger et al., 2005). More specifically, the LFP power in the 0–10 Hz band sharply rises while the power in the 20–40 Hz band falls as the state transitions from plan to execution. However, a change of visual stimulus immediately preceded reach onset, raising the possibility that the observed spectral change reflected the visual event instead of the reach onset. Here, we tested this possibility and found that the LFP spectrum change was still time locked to the movement onset in the absence of a visual event in self-paced reaches. Furthermore, we successfully trained the macaque subjects to use the LFP spectrum change as a "go" signal in a closed-loop brain-control task in which the animals only modulated the LFP and did not execute a reach. The execution onset was signaled by the change in the LFP spectrum while the target position of the cursor was controlled by the spike firing rates recorded from the same site. The results corroborate that the LFP spectrum change in PRR is a robust indicator for the movement onset and can be used for control of execution onset in a cortical prosthesis.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1523/JNEUROSCI.2081-09.2009 DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc2805702/PubMed CentralArticle
ORCID:
AuthorORCID
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2009 Society for Neuroscience. Received May 2, 2009; revised Sept. 7, 2009; accepted Sept. 14, 2009. This work was supported by the National Institute of Health, the James G. Boswell Foundation, and the Defense Advanced Research Projects Agency. We thank H. Cui, A. Graf, and M. Hauschild for comments on this manuscript, K. Pejsa and N. Sammons for animal care, and G. Mulliken, V. Shcherbatyuk, and T. Yao for technical and administrative assistance.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
Defense Advanced Research Projects AgencyUNSPECIFIED
Issue or Number:45
PubMed Central ID:PMC2805702
DOI:10.1523/JNEUROSCI.2081-09.2009
Record Number:CaltechAUTHORS:20091210-083246641
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20091210-083246641
Official Citation:Eun Jung Hwang, and Richard A. Andersen Brain Control of Movement Execution Onset Using Local Field Potentials in Posterior Parietal Cortex J. Neurosci. 29: 14363-14370; doi:10.1523/JNEUROSCI.2081-09.2009
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:16936
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 Jan 2010 00:22
Last Modified:08 Nov 2021 23:31

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