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Electron flow through proteins

Gray, Harry B. and Winkler, Jay R. (2009) Electron flow through proteins. Chemical Physics Letters, 483 (1-3). pp. 1-9. ISSN 0009-2614. PMCID PMC2800052. doi:10.1016/j.cplett.2009.10.051.

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Electron transfers in photosynthesis and respiration commonly occur between metal-containing cofactors that are separated by large molecular distances. Employing laser flash-quench triggering methods, we have shown that 20-Å, coupling-limited Fe^(II)–Ru^(III) and Cu^I–Ru^(III) electron tunneling in Ru-modified cytochromes and blue copper proteins can occur on the microsecond timescale both in solutions and crystals. Redox equivalents can be transferred even longer distances by multistep tunneling, often called hopping, through intervening amino acid side chains. Our work has established that 20-Å hole hopping through an intervening tryptophan is two orders of magnitude faster than single-step electron tunneling in a Re-modified blue copper protein.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Gray, Harry B.0000-0002-7937-7876
Winkler, Jay R.0000-0002-4453-9716
Additional Information:© 2009 Elsevier B.V. Received 13 October 2009; accepted 14 October 2009. Available online 17 October 2009. We thank NIH, NSF, GCEP (Stanford), CCSER (Gordon and Betty Moore Foundation), and the Arnold and Mabel Beckman Foundation for support of our research program.
Funding AgencyGrant Number
Global Climate and Energy Project (GCEP)UNSPECIFIED
Caltech Center for Sustainable Energy ResearchUNSPECIFIED
Arnold and Mabel Beckman FoundationUNSPECIFIED
Issue or Number:1-3
PubMed Central ID:PMC2800052
Record Number:CaltechAUTHORS:20091223-093852288
Persistent URL:
Official Citation:Harry B. Gray, Jay R. Winkler, Electron flow through proteins, Chemical Physics Letters, Volume 483, Issues 1-3, 24 November 2009, Pages 1-9, ISSN 0009-2614, DOI: 10.1016/j.cplett.2009.10.051. (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17023
Deposited By: Tony Diaz
Deposited On:04 Jan 2010 23:55
Last Modified:08 Nov 2021 23:32

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