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Damage to Association Fiber Tracts Impairs Recognition of the Facial Expression of Emotion

Philippi, Carissa L. and Mehta, Sonya and Grabowski, Thomas and Adolphs, Ralph and Rudrauf, David (2009) Damage to Association Fiber Tracts Impairs Recognition of the Facial Expression of Emotion. Journal of Neuroscience, 29 (48). pp. 15089-15099. ISSN 0270-6474. PMCID PMC2819193.

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An array of cortical and subcortical structures have been implicated in the recognition of emotion from facial expressions. It remains unknown how these regions communicate as parts of a system to achieve recognition, but white matter tracts are likely critical to this process. We hypothesized that (1) damage to white matter tracts would be associated with recognition impairment and (2) the degree of disconnection of association fiber tracts [inferior longitudinal fasciculus (ILF) and/or inferior fronto-occipital fasciculus (IFOF)] connecting the visual cortex with emotion-related regions would negatively correlate with recognition performance. One hundred three patients with focal, stable brain lesions mapped onto a reference brain were tested on their recognition of six basic emotional facial expressions. Association fiber tracts from a probabilistic atlas were coregistered to the reference brain. Parameters estimating disconnection were entered in a general linear model to predict emotion recognition impairments, accounting for lesion size and cortical damage. Damage associated with the right IFOF significantly predicted an overall facial emotion recognition impairment and specific impairments for sadness, anger, and fear. One subject had a pure white matter lesion in the location of the right IFOF and ILF. He presented specific, unequivocal emotion recognition impairments. Additional analysis suggested that impairment in fear recognition can result from damage to the IFOF and not the amygdala. Our findings demonstrate the key role of white matter association tracts in the recognition of the facial expression of emotion and identify specific tracts that may be most critical.

Item Type:Article
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Adolphs, Ralph0000-0002-8053-9692
Additional Information:© 2009 Society for Neuroscience. Received Feb. 16, 2009; revised Oct. 5, 2009; accepted Oct. 7, 2009. This work was supported by National Institutes of Health Grants P01 NS019632, R01 NS058658-01, and R01 MH080721-01 and by a grant from the Simons Foundation (R.A.). We thank Justin Feinstein and Kenneth Manzel for their help with the interpretation and characterization of the neuropsychological profile of subject 1981. We thank Daniel Tranel for his input on the issue of defining a cutoff for impairment as well as his neuropsychological expertise with regard to tests of object recognition. We also thank Douglas Langbehn for his input regarding statistics validation.
Funding AgencyGrant Number
NIHP01 NS019632
NIHR01 NS058658-01
NIHR01 MH080721-01
Simons FoundationUNSPECIFIED
Issue or Number:48
PubMed Central ID:PMC2819193
Record Number:CaltechAUTHORS:20091223-105139412
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Official Citation:Carissa L. Philippi, Sonya Mehta, Thomas Grabowski, Ralph Adolphs, and David Rudrauf Damage to Association Fiber Tracts Impairs Recognition of the Facial Expression of Emotion J. Neurosci. 29: 15089-15099; doi:10.1523/JNEUROSCI.0796-09.2009
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17028
Deposited By: Tony Diaz
Deposited On:05 Jan 2010 00:23
Last Modified:03 Oct 2019 01:21

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