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Overlapping Prediction Errors in Dorsal Striatum During Instrumental Learning With Juice and Money Reward in the Human Brain

Valentin, Vivian V. and O'Doherty, John P. (2009) Overlapping Prediction Errors in Dorsal Striatum During Instrumental Learning With Juice and Money Reward in the Human Brain. Journal of Neurophysiology, 102 (6). pp. 3384-3391. ISSN 0022-3077. https://resolver.caltech.edu/CaltechAUTHORS:20100104-111342398

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Abstract

Prediction error signals have been reported in human imaging studies in target areas of dopamine neurons such as ventral and dorsal striatum during learning with many different types of reinforcers. However, a key question that has yet to be addressed is whether prediction error signals recruit distinct or overlapping regions of striatum and elsewhere during learning with different types of reward. To address this, we scanned 17 healthy subjects with functional magnetic resonance imaging while they chose actions to obtain either a pleasant juice reward (1 ml apple juice), or a monetary gain (5 cents) and applied a computational reinforcement learning model to subjects' behavioral and imaging data. Evidence for an overlapping prediction error signal during learning with juice and money rewards was found in a region of dorsal striatum (caudate nucleus), while prediction error signals in a subregion of ventral striatum were significantly stronger during learning with money but not juice reward. These results provide evidence for partially overlapping reward prediction signals for different types of appetitive reinforcers within the striatum, a finding with important implications for understanding the nature of associative encoding in the striatum as a function of reinforcer type.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1152/jn.91195.2008 DOIArticle
http://jn.physiology.org/cgi/content/abstract/102/6/3384PublisherArticle
ORCID:
AuthorORCID
O'Doherty, John P.0000-0003-0016-3531
Additional Information:© 2009 American Physiological Society. Submitted 10 November 2008; accepted in final form 28 September 2009. We thank I. Kagan, S. Wagner, and M. Tyszka for technical assistance and advice. This research is supported by a Searle Scholarship and a grant from the National Science Foundation to J. P. O’Doherty.
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Funding AgencyGrant Number
NSFUNSPECIFIED
Searle Scholars ProgramUNSPECIFIED
Issue or Number:6
Record Number:CaltechAUTHORS:20100104-111342398
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20100104-111342398
Official Citation:Vivian V. Valentin, and John P. O'Doherty Overlapping Prediction Errors in Dorsal Striatum During Instrumental Learning With Juice and Money Reward in the Human Brain J Neurophysiol 102: 3384-3391, 2009. First published doi:10.1152/jn.91195.2008
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17047
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 Jan 2010 19:53
Last Modified:09 Mar 2020 13:19

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