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Function-based Intersubject Alignment of Human Cortical Anatomy

Sabuncu, Mert R. and Singer, Benjamin D. and Conroy, Bryan and Bryan, Ronald E. and Ramadge, Peter J. and Haxby, James V. (2010) Function-based Intersubject Alignment of Human Cortical Anatomy. Cerebral Cortex, 20 (1). pp. 130-140. ISSN 1047–3211.

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Making conclusions about the functional neuroanatomical organization of the human brain requires methods for relating the functional anatomy of an individual's brain to population variability. We have developed a method for aligning the functional neuroanatomy of individual brains based on the patterns of neural activity that are elicited by viewing a movie. Instead of basing alignment on functionally defined areas, whose location is defined as the center of mass or the local maximum response, the alignment is based on patterns of response as they are distributed spatially both within and across cortical areas. The method is implemented in the two-dimensional manifold of an inflated, spherical cortical surface. The method, although developed using movie data, generalizes successfully to data obtained with another cognitive activation paradigm—viewing static images of objects and faces—and improves group statistics in that experiment as measured by a standard general linear model (GLM) analysis.

Item Type:Article
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Sabuncu, Mert R.0000-0002-7068-719X
Additional Information:© The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Cerebral Cortex Advance Access originally published online on May 6, 2009. National Institute of Mental Health (grant no. 5R01MH075706). We would like to thank Ziad Saad for assistance and consultation with using software for cortical surface manipulation, and Ida Gobbini for assistance with data collection. Conflict of Interest: None declared.
Funding AgencyGrant Number
National Institute of Mental Health5R01MH075706
Subject Keywords:between-subject alignment; fMRI; human cortex; neuroimaging
Issue or Number:1
Record Number:CaltechAUTHORS:20100119-143152911
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Official Citation:Mert R. Sabuncu , Benjamin D. Singer , Bryan Conroy , Ronald E. Bryan , Peter J. Ramadge , and James V. Haxby Function-based Intersubject Alignment of Human Cortical Anatomy Cerebral Cortex Advance Access published on January 1, 2010, DOI 10.1093/cercor/bhp085. Cereb. Cortex 20: 130-140.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17221
Deposited By: Jason Perez
Deposited On:28 Jan 2010 19:36
Last Modified:09 Mar 2020 13:19

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