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Controlling biological networks by time-delayed signals

Orosz, Gábor and Moehlis, Jeff and Murray, Richard M. (2010) Controlling biological networks by time-delayed signals. Philosophical Transactions A: Mathematical, Physical and Engineering Sciences, 368 (1911). pp. 439-454. ISSN 1364-503X.

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This paper describes the use of time-delayed feedback to regulate the behaviour of biological networks. The general ideas on specific transcriptional regulatory and neural networks are demonstrated. It is shown that robust yet tunable controllers can be constructed that provide the biological systems with model-engineered inputs. The results indicate that time delay modulation may serve as an efficient biocompatible control tool.

Item Type:Article
Related URLs:
URLURL TypeDescription DOIArticle
Orosz, Gábor0000-0002-9000-3736
Murray, Richard M.0000-0002-5785-7481
Additional Information:© 2010 The Royal Society. One contribution of 13 to a Theme Issue ‘Delayed complex systems’. This research was sponsored by the National Science Foundation under grant NSF-0547606 and by the Institute for Collaborative Biotechnologies under grant DAAD19-03-D004 from the US Army Research Office.
Funding AgencyGrant Number
Army Research Office (ARO)DAAD19-03-D004
Subject Keywords:time delay; control; gene regulatory network; neural network
Issue or Number:1911
Record Number:CaltechAUTHORS:20100120-105437457
Persistent URL:
Official Citation:Gábor Orosz, Jeff Moehlis, and Richard M. Murray Controlling biological networks by time-delayed signals Phil. Trans. R. Soc. A January 28, 2010 368:439-454; doi:10.1098/rsta.2009.0242
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17241
Deposited By: Jason Perez
Deposited On:25 Jan 2010 23:47
Last Modified:10 Sep 2020 22:41

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