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Multiplicative Auditory Spatial Receptive Fields Created by a Hierarchy of Population Codes

Fischer, Brian J. and Anderson, Charles H. and Peña, José Luis (2009) Multiplicative Auditory Spatial Receptive Fields Created by a Hierarchy of Population Codes. PLoS ONE, 4 (11). Art. No. e8015 . ISSN 1932-6203. PMCID PMC2776990.

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A multiplicative combination of tuning to interaural time difference (ITD) and interaural level difference (ILD) contributes to the generation of spatially selective auditory neurons in the owl's midbrain. Previous analyses of multiplicative responses in the owl have not taken into consideration the frequency-dependence of ITD and ILD cues that occur under natural listening conditions. Here, we present a model for the responses of ITD- and ILD-sensitive neurons in the barn owl's inferior colliculus which satisfies constraints raised by experimental data on frequency convergence, multiplicative interaction of ITD and ILD, and response properties of afferent neurons. We propose that multiplication between ITD- and ILD-dependent signals occurs only within frequency channels and that frequency integration occurs using a linear-threshold mechanism. The model reproduces the experimentally observed nonlinear responses to ITD and ILD in the inferior colliculus, with greater accuracy than previous models. We show that linear-threshold frequency integration allows the system to represent multiple sound sources with natural sound localization cues, whereas multiplicative frequency integration does not. Nonlinear responses in the owl's inferior colliculus can thus be generated using a combination of cellular and network mechanisms, showing that multiple elements of previous theories can be combined in a single system.

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Anderson, Charles H.0000-0003-1141-3559
Additional Information:© 2009 Fischer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Received April 23, 2009; Accepted October 6, 2009. Published online 2009 November 24. We are grateful to Mark Konishi for his mentoring and support and to Emilio Salinas for commenting on a preliminary draft of this paper. We thank Kip Keller, Klaus Hartung, and Terry Takahashi for providing the barn owl head-related transfer functions. Funding: NIH grant DC007690. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Author Contributions: Conceived and designed the experiments: BJF JLP. Performed the experiments: BJF JLP. Analyzed the data: BJF CHA JLP. Wrote the paper: BJF CHA JLP.
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Subject Keywords:Neuroscience, Computational Biology
Issue or Number:11
PubMed Central ID:PMC2776990
Record Number:CaltechAUTHORS:20100120-143619278
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Official Citation: Fischer BJ, Anderson CH, Peña JL, 2009 Multiplicative Auditory Spatial Receptive Fields Created by a Hierarchy of Population Codes. PLoS ONE 4(11): e8015. doi:10.1371/journal.pone.0008015
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17249
Deposited By: Tony Diaz
Deposited On:25 Jan 2010 19:54
Last Modified:09 Mar 2020 13:18

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