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Modularity and design principles in the sea urchin embryo gene regulatory network

Peter, Isabelle S. and Davidson, Eric H. (2009) Modularity and design principles in the sea urchin embryo gene regulatory network. FEBS Letters, 583 (24). pp. 3948-3958. ISSN 0014-5793. PMCID PMC2810318. doi:10.1016/j.febslet.2009.11.060. https://resolver.caltech.edu/CaltechAUTHORS:20100120-152548304

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Abstract

The gene regulatory network (GRN) established experimentally for the pre-gastrular sea urchin embryo provides causal explanations of the biological functions required for spatial specification of embryonic regulatory states. Here we focus on the structure of the GRN which controls the progressive increase in complexity of territorial regulatory states during embryogenesis; and on the types of modular subcircuits of which the GRN is composed. Each of these subcircuit topologies executes a particular operation of spatial information processing. The GRN architecture reflects the particular mode of embryogenesis represented by sea urchin development. Network structure not only specifies the linkages constituting the genomic regulatory code for development, but also indicates the various regulatory requirements of regional developmental processes.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.febslet.2009.11.060DOIArticle
http://linkinghub.elsevier.com/retrieve/pii/S0014579309009739PublisherArticle
http://www.febsletters.org/article/S0014-5793%2809%2900973-9/abstractPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810318/PubMed CentralArticle
ORCID:
AuthorORCID
Peter, Isabelle S.0000-0003-3685-3147
Additional Information:© 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. Received 14 November 2009; accepted 16 November 2009. Available online 20 November 2009. Edited by Stefan Hohmann. Research was supported by NIH grant HD37105 and the Lucille P. Markey Charitable Trust. I.P. was supported by a fellowship from the Swiss National Science Foundation.
Funders:
Funding AgencyGrant Number
NIHHD37105
Lucille P. Markey Charitable TrustUNSPECIFIED
Swiss National Science Foundation (SNSF)UNSPECIFIED
Subject Keywords:Subcircuit structure/function; Spatial transcriptional regulation; Embryonic specification
Issue or Number:24
PubMed Central ID:PMC2810318
DOI:10.1016/j.febslet.2009.11.060
Record Number:CaltechAUTHORS:20100120-152548304
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20100120-152548304
Official Citation:Modularity and design principles in the sea urchin embryo gene regulatory network Isabelle S. Peter, Eric H. Davidson FEBS Letters - 17 December 2009 (Vol. 583, Issue 24, Pages 3948-3958, DOI: 10.1016/j.febslet.2009.11.060)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17251
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:25 Jan 2010 19:19
Last Modified:08 Nov 2021 23:34

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