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Value Computations in Ventral Medial Prefrontal Cortex during Charitable Decision Making Incorporate Input from Regions Involved in Social Cognition

Hare, Todd A. and Camerer, Colin F. and Knoepfle, Daniel T. and O'Doherty, John P. and Rangel, Antonio (2010) Value Computations in Ventral Medial Prefrontal Cortex during Charitable Decision Making Incorporate Input from Regions Involved in Social Cognition. Journal of Neuroscience, 30 (20). pp. 583-590. ISSN 0270-6474. PMCID PMC6633003. doi:10.1523/JNEUROSCI.4089-09.2010. https://resolver.caltech.edu/CaltechAUTHORS:20100125-095921017

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Abstract

Little is known about the neural networks supporting value computation during complex social decisions. We investigated this question using functional magnetic resonance imaging while subjects made donations to different charities. We found that the blood oxygenation level-dependent signal in ventral medial prefrontal cortex (VMPFC) correlated with the subjective value of voluntary donations. Furthermore, the region of the VMPFC identified showed considerable overlap with regions that have been shown to encode for the value of basic rewards at the time of choice, suggesting that it might serve as a common valuation system during decision making. In addition, functional connectivity analyses indicated that the value signal in VMPFC might integrate inputs from networks, including the anterior insula and posterior superior temporal cortex, that are thought to be involved in social cognition.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/JNEUROSCI.4089-09.2010DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633003PubMed CentralArticle
ORCID:
AuthorORCID
Camerer, Colin F.0000-0003-4049-1871
O'Doherty, John P.0000-0003-0016-3531
Additional Information:© 2010 Society for Neuroscience. Received Aug. 19, 2009; revised Oct. 12, 2009; accepted Nov. 10, 2009. We thank the Betty and Gordon Moore Foundation for their financial support, Hilke Plassmann for sharing the data used to construct Figure 6, and Cendri Hutcherson for valuable comments on this manuscript.
Funders:
Funding AgencyGrant Number
Gordon and Betty Moore FoundationUNSPECIFIED
Issue or Number:20
PubMed Central ID:PMC6633003
DOI:10.1523/JNEUROSCI.4089-09.2010
Record Number:CaltechAUTHORS:20100125-095921017
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20100125-095921017
Official Citation:Todd A. Hare, Colin F. Camerer, Daniel T. Knoepfle, John P. O'Doherty, and Antonio Rangel Value Computations in Ventral Medial Prefrontal Cortex during Charitable Decision Making Incorporate Input from Regions Involved in Social Cognition J. Neurosci. 30: 583-590; doi:10.1523/JNEUROSCI.4089-09.2010
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17300
Collection:CaltechAUTHORS
Deposited By:INVALID USER
Deposited On:28 Jan 2010 19:57
Last Modified:08 Nov 2021 23:34

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