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High efficiency, low distortion 3D diffusion tensor imaging with variable density spiral fast spin echoes (3D DW VDS RARE)

Frank, Lawrence R. and Jung, Youngkyoo and Inati, Souheil and Tyszka, J. Michael and Wong, Eric C. (2010) High efficiency, low distortion 3D diffusion tensor imaging with variable density spiral fast spin echoes (3D DW VDS RARE). NeuroImage, 49 (2). pp. 1510-1523. ISSN 1053-8119. PMCID PMC2791091.

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We present an acquisition and reconstruction method designed to acquire high resolution 3D fast spin echo diffusion tensor images while mitigating the major sources of artifacts in DTI-field distortions, eddy currents and motion. The resulting images, being 3D, are of high SNR, and being fast spin echoes, exhibit greatly reduced field distortions. This sequence utilizes variable density spiral acquisition gradients, which allow for the implementation of a self-navigation scheme by which both eddy current and motion artifacts are removed. The result is that high resolution 3D DTI images are produced without the need for eddy current compensating gradients or B_0 field correction. In addition, a novel method for fast and accurate reconstruction of the non-Cartesian data is employed. Results are demonstrated in the brains of normal human volunteers.

Item Type:Article
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URLURL TypeDescription DOIArticle CentralArticle
Tyszka, J. Michael0000-0001-9342-9014
Additional Information:© 2009 Elsevier Inc. Received 20 March 2009; revised 1 September 2009; accepted 11 September 2009. Available online 22 September 2009. We would like to thank Dr Kun Lu for his assistance in pulse sequence matters, Dr. Tie-Q Li for his assistance with the variable density spiral implementation, and Dr. Greg Balls for assistance in implementing the parallel version of the reconstruction code. This work was supported in part by NIH grants 5R01-MH64729-05, 5R01- MH075870-02, 5R01-AA10417 (lrf) and the Gordon and Betty Moore Foundation (JMT).
Funding AgencyGrant Number
Gordon and Betty Moore FoundationUNSPECIFIED
Subject Keywords:Diffusion; Three-dimensional; Diffusion tensor imaging; Diffusion anisotropy; High angular resolution diffusion; 3D fast spin echo; 3D RARE; Spiral; Self-navigation
Issue or Number:2
PubMed Central ID:PMC2791091
Record Number:CaltechAUTHORS:20100129-092526853
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17349
Deposited By: Tony Diaz
Deposited On:01 Feb 2010 02:50
Last Modified:03 Oct 2019 01:26

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