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Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual Action

Balleine, Bernard W. and O'Doherty, John P. (2010) Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual Action. Neuropsychopharmacology, 35 (1). pp. 48-69. ISSN 0893-133X. PMCID PMC3055420.

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Recent behavioral studies in both humans and rodents have found evidence that performance in decision-making tasks depends on two different learning processes; one encoding the relationship between actions and their consequences and a second involving the formation of stimulus–response associations. These learning processes are thought to govern goal-directed and habitual actions, respectively, and have been found to depend on homologous corticostriatal networks in these species. Thus, recent research using comparable behavioral tasks in both humans and rats has implicated homologous regions of cortex (medial prefrontal cortex/medial orbital cortex in humans and prelimbic cortex in rats) and of dorsal striatum (anterior caudate in humans and dorsomedial striatum in rats) in goal-directed action and in the control of habitual actions (posterior lateral putamen in humans and dorsolateral striatum in rats). These learning processes have been argued to be antagonistic or competing because their control over performance appears to be all or none. Nevertheless, evidence has started to accumulate suggesting that they may at times compete and at others cooperate in the selection and subsequent evaluation of actions necessary for normal choice performance. It appears likely that cooperation or competition between these sources of action control depends not only on local interactions in dorsal striatum but also on the cortico-basal ganglia network within which the striatum is embedded and that mediates the integration of learning with basic motivational and emotional processes. The neural basis of the integration of learning and motivation in choice and decision-making is still controversial and we review some recent hypotheses relating to this issue.

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O'Doherty, John P.0000-0003-0016-3531
Additional Information:© 2010 Nature Publishing Group. Received 14 April 2009; revised 29 July 2009; accepted 30 July 2009; published online 23 September 2009. The preparation of this paper was supported by grants from NICHD #HD59257 and NINDS #RR24911 to Bernard Balleine and a grant from Science Foundation Ireland to John O'Doherty.
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Science Foundation, IrelandUNSPECIFIED
Subject Keywords:decision-making; instrumental conditioning; prefrontal cortex; dorsal striatum; nucleus accumbens; amygdala
Issue or Number:1
PubMed Central ID:PMC3055420
Record Number:CaltechAUTHORS:20100203-111645746
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17379
Deposited By: Jason Perez
Deposited On:16 Feb 2010 20:04
Last Modified:25 Oct 2019 18:12

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