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Responses of Human Medial Temporal Lobe Neurons Are Modulated by Stimulus Repetition

Pedreira, Carlos and Mormann, Florian and Kraskov, Alexander and Cerf, Moran and Fried, Itzhak and Koch, Christof and Quiroga, Rodrigo Quian (2010) Responses of Human Medial Temporal Lobe Neurons Are Modulated by Stimulus Repetition. Journal of Neurophysiology, 103 (1). pp. 97-107. ISSN 0022-3077. PMCID PMC2807242.

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Recent studies have reported the presence of single neurons with strong responses to visual inputs in the human medial temporal lobe. Here we show how repeated stimulus presentation—photos of celebrities and familiar individuals, landmark buildings, animals, and objects—modulates the firing rate of these cells: a consistent decrease in the neural activity was registered as images were repeatedly shown during experimental sessions. The effect of repeated stimulus presentation was not the same for all medial temporal lobe areas. These findings are consistent with the view that medial temporal lobe neurons link visual percepts to declarative memory.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Mormann, Florian0000-0003-1305-8028
Fried, Itzhak0000-0002-5962-2678
Koch, Christof0000-0001-6482-8067
Additional Information:© 2010 American Physiological Society. Submitted 15 December 2008; accepted in final form 20 October 2009. We thank all the patients for participating in our study and M. J. Ison, J. Martinez, and S. Thill for discussions. This work was supported by grants from the Engineering and Physical Sciences Research Council, Medical Research Council, National Institute of Neurological Disorders and Stroke, National Institute of Mental Health, Defense Advanced Research Projects Agency, and the Mathers Foundation. F. Mormann acknowledges support from Marie Curie Outgoing International Fellowship from the European Commission.
Group:Koch Laboratory (KLAB)
Funding AgencyGrant Number
Engineering and Physical Sciences Research Council (EPSRC)UNSPECIFIED
Medical Research Council (MRC)UNSPECIFIED
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Mathers FoundationUNSPECIFIED
Marie Curie FellowshipUNSPECIFIED
Issue or Number:1
PubMed Central ID:PMC2807242
Record Number:CaltechAUTHORS:20100208-114619968
Persistent URL:
Official Citation:Carlos Pedreira, Florian Mormann, Alexander Kraskov, Moran Cerf, Itzhak Fried, Christof Koch, and Rodrigo Quian Quiroga Responses of Human Medial Temporal Lobe Neurons Are Modulated by Stimulus Repetition J Neurophysiol 103: 97-107, 2010. First published doi:10.1152/jn.91323.2008
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17420
Deposited By: Jason Perez
Deposited On:16 Feb 2010 20:10
Last Modified:03 Oct 2019 01:27

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