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Physiological and pathological roles for microRNAs in the immune system

O'Connell, Ryan M. and Rao, Dinesh S. and Chaudhuri, Aadel A. and Baltimore, David (2010) Physiological and pathological roles for microRNAs in the immune system. Nature Reviews. Immunology, 10 (2). pp. 111-122. ISSN 1474-1733. http://resolver.caltech.edu/CaltechAUTHORS:20100217-110341370

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Abstract

Mammalian microRNAs (miRNAs) have recently been identified as important regulators of gene expression, and they function by repressing specific target genes at the post-transcriptional level. Now, studies of miRNAs are resolving some unsolved issues in immunology. Recent studies have shown that miRNAs have unique expression profiles in cells of the innate and adaptive immune systems and have pivotal roles in the regulation of both cell development and function. Furthermore, when miRNAs are aberrantly expressed they can contribute to pathological conditions involving the immune system, such as cancer and autoimmunity; they have also been shown to be useful as diagnostic and prognostic indicators of disease type and severity. This Review discusses recent advances in our understanding of both the intended functions of miRNAs in managing immune cell biology and their pathological roles when their expression is dysregulated.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/nri2708 DOIArticle
http://www.nature.com/nri/journal/v10/n2/abs/nri2708.htmlPublisherArticle
http://rdcu.be/e1YbPublisherFree ReadCube access
ORCID:
AuthorORCID
Rao, Dinesh S.0000-0002-0794-9337
Baltimore, David0000-0001-8723-8190
Additional Information:© 2010 Macmillan Publishers Limited. The writing of this review was supported by the United States National Institutes of Health (US NIH)(D.B), the Irvington Institute Fellowship Program of the Cancer Research Institute (R.M.O’C.), the US NIH 1K08CA133521 (D.S.R.) and the Graduate Research Fellowship Program of the National Science Foundation (A.A.C.).
Funders:
Funding AgencyGrant Number
NIH1K08CA133521
NSF Graduate Research FellowshipUNSPECIFIED
Cancer Research InstituteUNSPECIFIED
Record Number:CaltechAUTHORS:20100217-110341370
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20100217-110341370
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17500
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:19 Feb 2010 18:12
Last Modified:07 Nov 2017 22:41

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