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Apolipoprotein D: An overview of its role in aging and age-related diseases

Muffat, Julien and Walker, David W. (2010) Apolipoprotein D: An overview of its role in aging and age-related diseases. Cell Cycle, 9 (2). pp. 269-273. ISSN 1538-4101.

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“It’s got to be doing something important!”-Seymour Benzer, reflecting on the observation that ApoD mRNA levels increase 500-fold following neuronal crush injury. Seymour Benzer’s curiosity was legendary and seemingly limitless.1-5 Towards the end of his life, one of the (many) questions that kept him awake at night concerned the emerging role of Apolipoprotein D (ApoD) in aging and neurological disease. In this perspective, we will discuss the clinical and biochemical data on ApoD, and the input from the recent genetic studies in model systems, including those from the Benzer lab.

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Additional Information:© 2010 Landes Bioscience. Submitted: 10/09/09. Accepted: 10/26/09. We dedicate this perspective to our mentor Seymour Benzer. D.W.W. is funded by the American Federation for Aging Research to study the mechanisms of ApoD-mediated longevity in flies. D.W.W. received support from the UCLA Older Americans Independence Center, NIH/NIA Grant P30-AG028748 and the content does not necessarily represent the official views of the National Institute on Aging or the National Institutes of Health. D.W.W. also received support from the Ellison Medical Foundation and the UCLA Center for gene environment in Parkinson’s Disease. D.W.W. is an Ellison Medical Foundation New Scholar in Aging.
Funding AgencyGrant Number
American Federation for Aging ResearchUNSPECIFIED
UCLA Older Americans Independence CenterUNSPECIFIED
NIH/National Institute on Aging (NIA)P30-AG028748
Ellison Medical FoundationUNSPECIFIED
UCLA Center for gene environment in Parkinson’s DiseaseUNSPECIFIED
Subject Keywords:ApoD; GLaz; NLaz; drosophila; aging; p53; cancer
Issue or Number:2
Record Number:CaltechAUTHORS:20100225-095638796
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17596
Deposited By: Tony Diaz
Deposited On:03 Mar 2010 00:02
Last Modified:03 Oct 2019 01:30

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