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Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis

Elizarov, Arkadij M. and van Dam, R. Michael and Shin, Young Shik and Kolb, Hartmuth C. and Padgett, Henry C. and Stout, David and Shu, Jenny and Huang, Jiang and Daridon, Antoine and Heath, James R. (2010) Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis. Journal of Nuclear Medicine, 51 (2). pp. 282-287. ISSN 0161-5505 . PMCID PMC3000316. http://resolver.caltech.edu/CaltechAUTHORS:20100302-092458141

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Abstract

An integrated elastomeric microfluidic device, with a footprint the size of a postage stamp, has been designed and optimized for multistep radiosynthesis of PET tracers. Methods: The unique architecture of the device is centered around a 5-µL coin-shaped reactor, which yields reaction efficiency and speed from a combination of high reagent concentration, pressurized reactions, and rapid heat and mass transfer. Its novel features facilitate mixing, solvent exchange, and product collection. New mixing mechanisms assisted by vacuum, pressure, and chemical reactions are exploited. Results: The architecture of the reported reactor is the first that has allowed batch-mode microfluidic devices to produce radiopharmaceuticals of sufficient quality and quantity to be validated by in vivo imaging. Conclusion: The reactor has the potential to produce multiple human doses of ^(18)F-FDG; the most impact, however, is expected in the synthesis of PET radiopharmaceuticals that can be made only with low yields by currently available equipment.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.2967/jnumed.109.065946 DOIArticle
http://jnm.snmjournals.org/cgi/content/abstract/51/2/282PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000316/PubMed CentralArticle
ORCID:
AuthorORCID
Heath, James R.0000-0001-5356-4385
Additional Information:© 2010 by the Society of Nuclear Medicine, Inc. Received May 12, 2009; revision accepted Nov. 9, 2009. We acknowledge Carl Meinhart of UC Santa Barbara for theoretic investigations of on-chip processes, which will be published separately. This work was funded by Siemens Molecular Imaging, Biomarker Research, Culver City, California.
Funders:
Funding AgencyGrant Number
Siemens Molecular ImagingUNSPECIFIED
Subject Keywords:radiosynthesis; microfluidics; PET; F-18-FDG; instrumentation
Issue or Number:2
PubMed Central ID:PMC3000316
Record Number:CaltechAUTHORS:20100302-092458141
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20100302-092458141
Official Citation:Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis Arkadij M. Elizarov, R. Michael van Dam, Young Shik Shin, Hartmuth C. Kolb, Henry C. Padgett, David Stout, Jenny Shu, Jiang Huang, Antoine Daridon, and James R. Heath J Nucl Med 51: 282-287.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17625
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Mar 2010 17:15
Last Modified:25 Apr 2017 05:09

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