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Rapid Assembly of the Salvileucalin B Norcaradiene Core

Levin, Sergiy and Nani, Roger R. and Reisman, Sarah E. (2010) Rapid Assembly of the Salvileucalin B Norcaradiene Core. Organic Letters, 12 (4). pp. 780-783. ISSN 1523-7060. https://resolver.caltech.edu/CaltechAUTHORS:20100303-133732724

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Abstract

Preparation of the polycyclic core of the cytotoxic natural product salvileucalin B is described. The key feature of this synthetic strategy is a copper-catalyzed intramolecular arene cyclopropanation to provide the central norcaradiene. These studies lay the foundation for continued investigations toward an enantioselective total synthesis of 1.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ol902848kDOIArticle
ORCID:
AuthorORCID
Levin, Sergiy0000-0003-2242-5459
Reisman, Sarah E.0000-0001-8244-9300
Additional Information:© 2010 American Chemical Society. Received December 10, 2009. Publication Date (Web): January 20, 2010. We thank Dr. Scott Virgil and Dr. Jennifer Roizen of the California Institute of Technology for insightful discussions, as well as Prof. Brian Stoltz and the Caltech Center for Catalysis and Chemical Synthesis for access to analytical equipment. Financial support from the California Institute of Technology is gratefully acknowledged.
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CaltechUNSPECIFIED
Issue or Number:4
Record Number:CaltechAUTHORS:20100303-133732724
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20100303-133732724
Official Citation:Rapid Assembly of the Salvileucalin B Norcaradiene Core Sergiy Levin, Roger R. Nani, Sarah E. Reisman Organic Letters 2010 12 (4), 780-783
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17649
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Mar 2010 18:30
Last Modified:09 Mar 2020 13:19

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