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Elucidating ANTs in worms using genomic and bioinformatic tools — Biotechnological prospects?

Hu, Min and Zhong, Weiwei and Campbell, Bronwyn E. and Sternberg, Paul W. and Pellegrino, Mark W. and Gasser, Robin B. (2010) Elucidating ANTs in worms using genomic and bioinformatic tools — Biotechnological prospects? Biotechnology Advances, 28 (1). pp. 49-60. ISSN 0734-9750. https://resolver.caltech.edu/CaltechAUTHORS:20100303-151930574

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Abstract

Adenine nucleotide translocators (ANTs) belong to the mitochondrial carrier family (MCF) of proteins. ATP production and consumption are tightly linked to ANTs, the kinetics of which have been proposed to play a key regulatory role in mitochondrial oxidative phosphorylation. ANTs are also recognized as a central component of the mitochondrial permeability transition pore associated with apoptosis. Although ANTs have been investigated in a range of vertebrates, including human, mouse and cattle, and invertebrates, such as Drosophila melanogaster (vinegar fly), Saccharomyces cerevisiae (yeast) and Caenorhabditis elegans (free-living nematode), there has been a void of information on these molecules for parasitic nematodes of socio-economic importance. Exploring ANTs in nematodes has the potential lead to a better understanding of their fundamental roles in key biological pathways and might provide an avenue for the identification of targets for the rational design of nematocidal drugs. In the present article, we describe the discovery of an ANT from Haemonchus contortus (one of the most economically important parasitic nematodes of sheep and goats), conduct a comparative analysis of key ANTs and their genes (particularly ant-1.1) in nematodes and other organisms, predict the functional roles utilizing a combined genomic-bioinformatic approach and propose ANTs and associated molecules as possible drug targets, with the potential for biotechnological outcomes.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.biotechadv.2009.09.001 DOIArticle
ORCID:
AuthorORCID
Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 2009 Elsevier Inc. Received 2 July 2009; revised 11 August 2009; accepted 3 September 2009. Available online 19 September 2009. Funding support to RBG from the Australian Research Council (LX0882231 and LX0989150), Genetic Technologies Limited and Meat and Livestock Australia are gratefully acknowledged. The authors thank Drs Warwick Grant, Kirsten Grant and Jagan Srinivasan for discussions and support as well as Alon Zaslaver for technical assistance.
Funders:
Funding AgencyGrant Number
Australian Research CouncilLX0882231
Australian Research CouncilLX0989150
Genetic Technologies LimitedUNSPECIFIED
Meat and Livestock AustraliaUNSPECIFIED
Subject Keywords:Adenine nucleotide translocator; ADP/ATP translocase; Nematodes; Caenorhabditis elegans; Haemonchus contortus; Genomics; Bioinformatics; Genetic interactions
Issue or Number:1
Record Number:CaltechAUTHORS:20100303-151930574
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20100303-151930574
Official Citation:Min Hu, Weiwei Zhong, Bronwyn E. Campbell, Paul W. Sternberg, Mark W. Pellegrino, Robin B. Gasser, Elucidating ANTs in worms using genomic and bioinformatic tools -- Biotechnological prospects?, Biotechnology Advances, Volume 28, Issue 1, January-February 2010, Pages 49-60, ISSN 0734-9750, DOI: 10.1016/j.biotechadv.2009.09.001. (http://www.sciencedirect.com/science/article/B6T4X-4X8CCXX-1/2/1eb37a07b24b04ff22681eaa659787b1)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17654
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Mar 2010 18:51
Last Modified:03 Mar 2020 13:01

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