CaltechAUTHORS
  A Caltech Library Service

Caspase-Dependent Cell Death in Drosophila

Hay, Bruce A. and Guo, Ming (2006) Caspase-Dependent Cell Death in Drosophila. Annual Review of Cell and Developmental Biology, 22 . pp. 623-650. ISSN 1081-0706. https://resolver.caltech.edu/CaltechAUTHORS:20100319-133820780

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20100319-133820780

Abstract

Cell death plays many roles during development, in the adult, and in the genesis of many pathological states. Much of this death is apoptotic in nature and requires the activity of members of the caspase family of proteases. It is now possible uniquely in Drosophila to carry out genetic screens for genes that determine the fate—life or death—of any population of cells during development and adulthood. This, in conjunction with the ability to obtain biochemical quantities of material, has made Drosophila a useful organism for exploring the mechanisms by which apoptosis is carried out and regulated. This review summarizes our knowledge of caspase-dependent cell death in Drosophila and compares that knowledge with what is known in worms and mammals. We also discuss the significance of recent work showing that a number of key cell death activators also play nonapoptotic roles. We highlight opportunities and outstanding questions along the way.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1146/annurev.cellbio.21.012804.093845DOIArticle
http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.cellbio.21.012804.093845PublisherArticle
Additional Information:© 2006 by Annual Reviews. First published online as a Review in Advance on July 14, 2006. This work was supported by NIH grant GM57422 to B.A.H. and NIH grants NS048396 and NS042580 to M.G. M.G. is a Sloan Foundation Fellow. The authors thank J.R. Huh for help with the figures and J.R. Huh, C-H. Chen, and I. Muro for providing unpublished observations and comments on the manuscript.
Funders:
Funding AgencyGrant Number
NIHGM57422
NIHNS048396
NIHNS042580
Alfred P. Sloan FoundationUNSPECIFIED
Subject Keywords:DIAP1, apoptosis, neurodegeneration, spermatogenesis, DIAP2, innate immunity, proliferation
Record Number:CaltechAUTHORS:20100319-133820780
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20100319-133820780
Official Citation:Hay, B. A. and M. Guo (2006). "Caspase-Dependent Cell Death in Drosophila." Annual Review of Cell and Developmental Biology 22(1): 623-650. DOI:http://dx.doi.org/10.1146/annurev.cellbio.21.012804.093845
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17782
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:22 Mar 2010 17:39
Last Modified:03 Oct 2019 01:33

Repository Staff Only: item control page