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DNA-Mediated Charge Transport in Redox Sensing and Signaling

Genereux, Joseph C. and Boal, Amie K. and Barton, Jacqueline K. (2010) DNA-Mediated Charge Transport in Redox Sensing and Signaling. Journal of the American Chemical Society, 132 (3). pp. 891-905. ISSN 0002-7863. PMCID PMC2902267. doi:10.1021/ja907669c.

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The transport of charge through the DNA base-pair stack offers a route to carry out redox chemistry at a distance. Here we describe characteristics of this chemistry that have been elucidated and how this chemistry may be utilized within the cell. The shallow distance dependence associated with these redox reactions permits DNA-mediated signaling over long molecular distances in the genome and facilitates the activation of redox-sensitive transcription factors globally in response to oxidative stress. The long-range funneling of oxidative damage to sites of low oxidation potential in the genome also may provide a means of protection within the cell. Furthermore, the sensitivity of DNA charge transport to perturbations in base-pair stacking, as may arise with base lesions and mismatches, may be used as a route to scan the genome for damage as a first step in DNA repair. Thus, the ability of double-helical DNA in mediating redox chemistry at a distance provides a natural mechanism for redox sensing and signaling in the genome.

Item Type:Article
Related URLs:
URLURL TypeDescription DOIArticle CentralArticle
Genereux, Joseph C.0000-0002-5093-7710
Boal, Amie K.0000-0002-1234-8472
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2010 American Chemical Society. Received September 9, 2009. Publication Date (Web): January 4, 2010. We thank the NIH for their financial support of the research described here. We also thank our co-workers and collaborators for their hard work, fortitude, courage, and creativity in elucidating this chemistry.
Funding AgencyGrant Number
Issue or Number:3
PubMed Central ID:PMC2902267
Record Number:CaltechAUTHORS:20100405-093806861
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17848
Deposited By: Tony Diaz
Deposited On:21 Apr 2010 15:55
Last Modified:08 Nov 2021 23:39

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