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Distributed neural system for general intelligence revealed by lesion mapping

Gläscher, J. and Rudrauf, D. and Colom, R. and Paul, L. K. and Tranel, D. and Damasio, H. and Adolphs, R. (2010) Distributed neural system for general intelligence revealed by lesion mapping. Proceedings of the National Academy of Sciences of the United States of America, 107 (10). pp. 4705-4709. ISSN 0027-8424. PMCID PMC2842050. https://resolver.caltech.edu/CaltechAUTHORS:20100408-133737274

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Abstract

General intelligence (g) captures the performance variance shared across cognitive tasks and correlates with real-world success. Yet it remains debated whether g reflects the combined performance of brain systems involved in these tasks or draws on specialized systems mediating their interactions. Here we investigated the neural substrates of g in 241 patients with focal brain damage using voxel-based lesion–symptom mapping. A hierarchical factor analysis across multiple cognitive tasks was used to derive a robust measure of g. Statistically significant associations were found between g and damage to a remarkably circumscribed albeit distributed network in frontal and parietal cortex, critically including white matter association tracts and frontopolar cortex. We suggest that general intelligence draws on connections between regions that integrate verbal, visuospatial, working memory, and executive processes.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1073/pnas.0910397107 DOIArticle
http://www.pnas.org/content/107/10/4705PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842050/PubMed CentralArticle
ORCID:
AuthorORCID
Paul, L. K.0000-0002-3128-8313
Adolphs, R.0000-0002-8053-9692
Additional Information:© 2010 by the National Academy of Sciences. Edited by Edward E. Smith, Columbia University, New York, NY, and approved January 25, 2010 (received for review September 10, 2009). Published online before print February 22, 2010. We thank Prof. M. Spezio for fruitful discussions of methodological issues; and Prof. M. Cassell (University of Iowa) for neuranatomical advice regarding white matter tracts. This work was supported by Akademie der Naturforscher Leopoldina Grant 9901/8-140 (to J.G.) and by National Institutes of Health Grants P01NS19632 (to D.T., H.D., and R.A.), R01DA022549 (to D.T.), and R01MH080721 (to R.A.), a grant by the Simons Foundation to R.A., as well as by the Tamagawa University global Centers of Excellence Program of the Japanese Ministry of Education, Culture, Sports, and Technology. R.C. was funded by Grant SEJ-2006-07890 from the Ministry of Education and Culture, Spain, and Grant PR2008-0038 from the Ministry of Science and Innovation, Spain. Author contributions: J.G. and R.A. designed research; D.T. and H.D. performed research; H.D. contributed new reagents/analytic tools; J.G., D.R., and R.C. analyzed data; and J.G., D.R., R.C., L.K.P., D.T., H.D., and R.A. wrote the paper.
Funders:
Funding AgencyGrant Number
Akademie der Naturforscher Leopoldina 9901/8-140
NIHP01NS19632
NIHR01DA022549
NIHR01MH080721
Simons Foundation UNSPECIFIED
Ministry of Education, Culture, Sports, Science and Technology (MEXT)UNSPECIFIED
Ministerio de Educación y Cultura (MEC)SEJ-2006-07890
Ministerio de Ciencia e Innovación (MICINN)PR2008-0038
Subject Keywords:lesion patients; voxel-based lesion-symptom mapping; Wechsler Adult Intelligence Scale; white matter
Issue or Number:10
PubMed Central ID:PMC2842050
Record Number:CaltechAUTHORS:20100408-133737274
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20100408-133737274
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17905
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:22 Apr 2010 16:20
Last Modified:03 Oct 2019 01:35

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