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Frequency and phase synchronization in neuromagnetic cortical responses to flickering-color stimuli

Timashev, S. F. and Polyakov, Yu. S. and Yulmetyev, R. M. and Demin, S. A. and Panischev, O. Yu. and Shimojo, S. and Bhattacharya, J. (2010) Frequency and phase synchronization in neuromagnetic cortical responses to flickering-color stimuli. Laser Physics, 20 (3). pp. 604-617. ISSN 1054-660X. https://resolver.caltech.edu/CaltechAUTHORS:20100517-111146433

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Abstract

In our earlier study dealing with the analysis of neuromagnetic responses (magnetoencephalograms—MEG) to flickering-color stimuli for a group of control human subjects (9 volunteers) and a patient with photosensitive epilepsy (a 12-year old girl), it was shown that Flicker-Noise Spectroscopy (FNS) was able to identify specific differences in the responses of each organism. The high specificity of individual MEG responses manifested itself in the values of FNS parameters for both chaotic and resonant components of the original signal. The present study applies the FNS cross-correlation function to the analysis of correlations between the MEG responses simultaneously measured at spatially separated points of the human cortex processing the red-blue flickering color stimulus. It is shown that the cross-correlations for control (healthy) subjects are characterized by frequency and phase synchronization at different points of the cortex, with the dynamics of neuromagnetic responses being determined by the low-frequency processes that correspond to normal physiological rhythms. But for the patient, the frequency and phase synchronization breaks down, which is associated with the suppression of cortical regulatory functions when the flickering-color stimulus is applied, and higher frequencies start playing the dominating role. This suggests that the disruption of correlations in the MEG responses is the indicator of pathological changes leading to photosensitive epilepsy, which can be used for developing a method of diagnosing the disease based on the analysis with the FNS cross-correlation function.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1134/S1054660X10050208 DOIArticle
ORCID:
AuthorORCID
Shimojo, S.0000-0002-1290-5232
Bhattacharya, J.0000-0003-3443-9049
Additional Information:© Pleiades Publishing, Ltd., 2010. Original Russian Text © Astro, Ltd., 2010. Received October 27, 2009; published online February 2, 2010. The article is published in the original. This study was supported in part by the Russian Foundation for Basic Research, projects no. 08-02- 00230-a and 08-02-00123-a.
Funders:
Funding AgencyGrant Number
Russian Foundation for Basic Research08-02-00230-a
Russian Foundation for Basic Research08-02-00123-a
Issue or Number:3
Record Number:CaltechAUTHORS:20100517-111146433
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20100517-111146433
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:18324
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:02 Jun 2010 18:32
Last Modified:03 Aug 2020 22:51

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