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The Gene Ontology in 2010: extensions and refinements

Berardini, Tanya Z. and Khodiyar, Varsha K. and Lovering, Ruth C. and Talmud, Philippa (2010) The Gene Ontology in 2010: extensions and refinements. Nucleic Acids Research, 38 (Databa). D331-D335. ISSN 0305-1048.

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The Gene Ontology (GO) Consortium ( (GOC) continues to develop, maintain and use a set of structured, controlled vocabularies for the annotation of genes, gene products and sequences. The GO ontologies are expanding both in content and in structure. Several new relationship types have been introduced and used, along with existing relationships, to create links between and within the GO domains. These improve the representation of biology, facilitate querying, and allow GO developers to systematically check for and correct inconsistencies within the GO. Gene product annotation using GO continues to increase both in the number of total annotations and in species coverage. GO tools, such as OBO-Edit, an ontology-editing tool, and AmiGO, the GOC ontology browser, have seen major improvements in functionality, speed and ease of use.

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Additional Information:© The Author(s) 2009. Received September 15, 2009; Revised October 16, 2009; Accepted October 19, 2009. The GO Consortium thanks the community researchers who have participated in content-related meetings or provided valuable feedback on ontology content and annotations. FUNDING National Human Genome Research Institute (NHGRI) (P41 HG02273 to GO PIs J.A.B., M.A., J.M.C., S.L.); GO Consortium member databases receive funding from several National Institutes of Health Institutes [National Human Genome Research Institute (HG000330 to M.G.D., HG02223 to Wormbase, HG004341 to K.E., HG003751 to Reactome, HG01315 to S.G.D., HG002659 to Z.F.I.N.); National Heart, Blood and Lung Institute (HL64541 to R.G.D.), National Institute of General Medical Sciences (U24GM077905, U24GM088849 to EcoliWiki)]; National Science Foundation (DBI# 0703908 to Gramene, DBI#0417062 to TAIR, EF-0523736 to PAMGO); UK Medical Research Council (G0500293 to FlyBase); British Heart Foundation (SP/07/007/23671); European Union Sixth Framework Programme (LSHG-CT-2003-503269 to Reactome). Funding for open access charge: National Human Genome Research Institute (grant #P41 HG02273).
Funding AgencyGrant Number
National Human Genome Research InstituteP41 HG02273
National Human Genome Research InstituteHG000330
National Human Genome Research InstituteHG02223
National Human Genome Research InstituteHG004341
National Human Genome Research InstituteHG003751
National Human Genome Research InstituteHG01315
National Human Genome Research InstituteHG002659
National Heart, Blood and Lung InstituteHL64541
National Institute of General Medical SciencesU24GM077905
National Institute of General Medical SciencesU24GM088849
NSFDBI# 0703908
UK Medical Research CouncilG0500293
British Heart FoundationSP/07/007/23671
European Union Sixth Framework ProgrammeLSHG-CT-2003-503269
National Human Genome Research InstituteP41 HG02273
Issue or Number:Databa
Record Number:CaltechAUTHORS:20100518-131952481
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Official Citation:The Gene Ontology in 2010: extensions and refinements The Gene Ontology ConsortiumThe Gene Ontology Consortium Nucleic Acids Res. 2010 January; 38(Database issue): D331–D335. Published online 2010 January. doi: 10.1093/nar/gkp1018. PMCID: PMC2808930
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:18343
Deposited By: Ruth Sustaita
Deposited On:24 Jun 2010 21:01
Last Modified:03 Oct 2019 01:41

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