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Space representation for eye movements is more contralateral in monkeys than in humans

Kagan, Igor and Iyer, Asha and Lindner, Axel and Andersen, Richard A. (2010) Space representation for eye movements is more contralateral in monkeys than in humans. Proceedings of the National Academy of Sciences of the United States of America, 107 (17). pp. 7933-7938. ISSN 0027-8424. PMCID PMC2867911. doi:10.1073/pnas.1002825107. https://resolver.caltech.edu/CaltechAUTHORS:20100526-074923099

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Abstract

Contralateral hemispheric representation of sensory inputs (the right visual hemifield in the left hemisphere and vice versa) is a fundamental feature of primate sensorimotor organization, in particular the visuomotor system. However, many higher-order cognitive functions in humans show an asymmetric hemispheric lateralization—e.g., right brain specialization for spatial processing—necessitating a convergence of information from both hemifields. Electrophysiological studies in monkeys and functional imaging in humans have investigated space and action representations at different stages of visuospatial processing, but the transition from contralateral to unified global spatial encoding and the relationship between these encoding schemes and functional lateralization are not fully understood. Moreover, the integration of data across monkeys and humans and elucidation of interspecies homologies is hindered, because divergent findings may reflect actual species differences or arise from discrepancies in techniques and measured signals (electrophysiology vs. imaging). Here, we directly compared spatial cue and memory representations for action planning in monkeys and humans using event-related functional MRI during a working-memory oculomotor task. In monkeys, cue and memory-delay period activity in the frontal, parietal, and temporal regions was strongly contralateral. In putative human functional homologs, the contralaterality was significantly weaker, and the asymmetry between the hemispheres was stronger. These results suggest an inverse relationship between contralaterality and lateralization and elucidate similarities and differences in human and macaque cortical circuits subserving spatial awareness and oculomotor goal-directed actions.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1073/pnas.1002825107 DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc2867911/PubMed CentralArticle
http://www.pnas.org/cgi/content/full/1002825107/DCSupplementalPublisherSupporting Information
ORCID:
AuthorORCID
Kagan, Igor0000-0002-1814-4200
Lindner, Axel0000-0002-8201-788X
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2010 by the National Academy of Sciences. Freely available online through the PNAS open access option. Contributed by Richard A. Andersen, March 17, 2010 (sent for review April 8, 2009). We thank S. Wagner for help with scanning; M. Wilke for comments on the manuscript; H. Glidden for useful discussions; K. Pejsa, L. Martel, and N. Sammons for animal care; and V. Shcherbatyuk for computer support. This work was supported by Moore Foundation, National Eye Institute, and Boswell Foundation. Author contributions: I.K. and R.A.A. designed research; I.K., A.I., and A.L. performed research; I.K., A.I., and A.L. contributed new reagents/analytic tools; I.K. and A.I. analyzed data; and I.K. and R.A.A. wrote the paper. The authors declare no conflict of interest. This article contains supporting information online at www.pnas.org/cgi/content/full/1002825107/DCSupplemental.
Funders:
Funding AgencyGrant Number
Gordon and Betty Moore FoundationUNSPECIFIED
National Eye InstituteUNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
NIHUNSPECIFIED
Subject Keywords:BOLD signal; event-related functional MRI; brain evolution; delayed saccades; lateralization
Issue or Number:17
PubMed Central ID:PMC2867911
DOI:10.1073/pnas.1002825107
Record Number:CaltechAUTHORS:20100526-074923099
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20100526-074923099
Official Citation:Space representation for eye movements is more contralateral in monkeys than in humans Igor Kagan, Asha Iyer, Axel Lindner, Richard A. Andersen Proceedings of the National Academy of Sciences Apr 2010, 107 (17) 7933-7938; DOI: 10.1073/pnas.1002825107
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:18441
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:19 Jun 2010 01:40
Last Modified:08 Nov 2021 23:44

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