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Wiring Nanoscale Biosensors with Piezoelectric Nanomechanical Resonators

Sadek, Akram S. and Karabalin, Rassul B. and Du, Jiangang and Roukes, Michael L. and Koch, Christof and Masmanidis, Sotiris C. (2010) Wiring Nanoscale Biosensors with Piezoelectric Nanomechanical Resonators. Nano Letters, 10 (5). pp. 1769-1773. ISSN 1530-6984. doi:10.1021/nl100245z.

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Nanoscale integrated circuits and sensors will require methods for unobtrusive interconnection with the macroscopic world to fully realize their potential. We report on a nanoelectromechanical system that may present a solution to the wiring problem by enabling information from multisite sensors to be multiplexed onto a single output line. The basis for this method is a mechanical Fourier transform mediated by piezoelectrically coupled nanoscale resonators. Our technique allows sensitive, linear, and real-time measurement of electrical potentials from conceivably any voltage-sensitive device. With this method, we demonstrate the direct transduction of neuronal action potentials from an extracellular microelectrode. This approach to wiring nanoscale devices could lead to minimally invasive implantable sensors with thousands of channels for in vivo neuronal recording, medical diagnostics, and electrochemical sensing.

Item Type:Article
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URLURL TypeDescription
Roukes, Michael L.0000-0002-2916-6026
Koch, Christof0000-0001-6482-8067
Additional Information:© 2010 American Chemical Society. Published In Issue: May 12, 2010; Article ASAP: April 09, 2010; Received: January 22, 2010; Revised: March 19, 2010. We thank I. De Vlaminck, W. van de Graaf, S. Degroote, and G. Borghs for the epitaxial GaAs substrates, G. Laurent for assistance with locust preparations and discussions, R. R. Harrison for the extracellular electronic amplifiers, M. R. Freeman for support with optical interferometry, and H. A. Lester for discussions. Device fabrication was carried out at the Kavli Nanoscience Institute, Caltech, and the NNIN Nanofabrication facility, UC Santa Barbara. This work was supported by the Broad Foundation under the Broad Fellowship Program in Brain Circuitry.
Group:Koch Laboratory (KLAB)
Funding AgencyGrant Number
Eli and Edythe Broad FoundationUNSPECIFIED
Subject Keywords:NEMS; multiplexing; neural probe
Issue or Number:5
Record Number:CaltechAUTHORS:20100601-111259385
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Official Citation:Wiring Nanoscale Biosensors with Piezoelectric Nanomechanical Resonators Akram S. Sadek, Rassul B. Karabalin, Jiangang Du, Michael L. Roukes, Christof Koch, Sotiris C. Masmanidis Nano Letters 2010 10 (5), 1769-1773
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:18502
Deposited On:02 Jun 2010 18:26
Last Modified:08 Nov 2021 23:44

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