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Human Medial Orbitofrontal Cortex Is Recruited During Experience of Imagined and Real Rewards

Bray, Signe and Shimojo, Shinsuke and O'Doherty, John P. (2010) Human Medial Orbitofrontal Cortex Is Recruited During Experience of Imagined and Real Rewards. Journal of Neurophysiology, 103 (5). pp. 2506-2512. ISSN 0022-3077. http://resolver.caltech.edu/CaltechAUTHORS:20100601-143143888

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Abstract

Human decision-making frequently relies on mental simulation of future rewards to guide action choice. In this study, we sought to uncover brain regions engaged during reward imagery and to address whether these regions functionally overlap with regions activated by tangible rewards. We found that medial orbitofrontal cortex (mOFC) is engaged both for real and imagined rewards and is preferentially engaged for imagery with rewarding content compared with other nonrewarding imagery. These findings support a critical role for mOFC in the representation of rewarding goal states, even if hypothetical.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1152/jn.01030.2009DOIUNSPECIFIED
http://jn.physiology.org/cgi/content/abstract/103/5/2506PublisherUNSPECIFIED
Additional Information:© 2010 The American Physiological Society. Submitted 28 November 2009; accepted in final form 24 February 2010. First published March 3, 2010. We thank the staff at the Caltech Brain Imaging Center. This research was funded by the Shimojo Japan Science and Technology- Exploratory Research for Advanced Technology Implicit Brain Function project, a Searle scholarship to J. P. O’Doherty, and a Dana foundation grant to J. P. O’Doherty.
Funders:
Funding AgencyGrant Number
Shimojo Japan Science and Technology-Exploratory Research for Advanced Technology Implicit Brain Function project UNSPECIFIED
Searle scholarshipUNSPECIFIED
Dana foundationUNSPECIFIED
Record Number:CaltechAUTHORS:20100601-143143888
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20100601-143143888
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:18510
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:23 Jun 2010 21:39
Last Modified:26 Dec 2012 12:05

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